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首页> 外文会议>Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2 >Local Versus Systemic Delivery of Endothelial Progenitor Cells for a Tissue Scaffold
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Local Versus Systemic Delivery of Endothelial Progenitor Cells for a Tissue Scaffold

机译：组织支架的内皮祖细胞的局部与全身递送。

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Revascularization of chronic wounds, such as pressure ulcers, or even tissue scaffolds is essential for protein production, collagen synthesis, and the destruction of bacteria. Poor blood supply is a rate-limiting step in the healing process. Attempts have been made to improve revascularization through angiogenesis-the formation of new blood vessels from the pre-existing network of vessels. However, angiogenesis is limited in that mature endothelial cells are already fully differentiated, have limited life span and proliferative ability, and have a reduced ability to incorporate into remote sites of ischemia. Recent studies have shown that vasculogenesis is also an important mechanism for revascularization of adult tissues. Vasculogenesis is defined as the formation of vessels from bone marrow-derived endothelial progenitor cells, or EPCs. EPCs, isolated from bone marrow, peripheral blood, or umbilical cord blood, have the ability to home to sites of tissue damage in the body, differentiate into mature endothelial cells, and incorporate into new vessel structures. The goal of this study was to compare the effectiveness of using these EPCs to stimulate healing when seeded locally in a tissue scaffold versus injected systemically. Specifically, it was hypothesized that using the EPCs locally would speed the healing process by stimulating both angiogenesis and vasculogenesis. Additionally, it was hypothesized that combining the local application of EPCs seeded into an albumin scaffold with a systemic injection of EPCs would be the best method for improving healing, by both increasing the number of EPCs in the blood traveling to the wound site and by reducing the amount of time required for the EPCs to initiate vasculogenesis at the wound site.
机译：慢性伤口（例如压疮或什至组织支架）的血运重建对蛋白质生产，胶原蛋白合成和细菌破坏至关重要。血液供应不足是愈合过程中的限速步骤。已经尝试通过血管生成来改善血管重建，血管生成是从先前存在的血管网络形成新血管。然而，血管生成受到限制，因为成熟的内皮细胞已经被完全分化，具有有限的寿命和增殖能力，并且掺入到局部缺血部位的能力降低。最近的研究表明，血管生成也是成人组织血运重建的重要机制。血管生成定义为由骨髓来源的内皮祖细胞或EPC形成血管。从骨髓，外周血或脐带血中分离出的EPC具有适应体内组织损伤部位，分化为成熟的内皮细胞并整合到新的血管结构中的能力。这项研究的目的是比较当局部植入组织支架中或全身注射时，使用这些EPC刺激愈合的有效性。具体而言，假设在局部使用EPC将通过刺激血管生成和血管生成来加快愈合过程。另外，有假设认为，通过增加流向伤口部位的血液中EPC的数量和减少通过将EPC的局部应用与植入白蛋白支架中的EPC与全身注射EPC相结合，将是改善愈合的最佳方法。 EPC在伤口部位启动血管生成所需的时间。

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