首页> 外文会议>Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2 >AFM Investigation of Fibroblast-Fibroblast Interactions on Collagen Substrates
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AFM Investigation of Fibroblast-Fibroblast Interactions on Collagen Substrates

机译:AFM研究胶原基质上的成纤维细胞-成纤维细胞相互作用

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Fibroblast-fibroblast adhesive interactions begin to form very quickly (within a couple of seconds) after physical contact is made. Given this time scale, these interactions are probably due to proteins on the cell surface that are already present at the start of the experiment. Longer time course studies are underway using a closed fluid cell to observe changes in interactions as junction proteins are synthesized. Unlike previous studies on myocyte interactions, there were no observable differences between cardiac fibroblast interactions on aligned vs. unaligned collagen. However, further studies on well defined patterned substrates need to be undertaken to determine whether collagen alignment does not affect fibroblast interactions.
机译:进行物理接触后,成纤维细胞与成纤维细胞之间的胶粘剂相互作用会很快形成(几秒钟之内)。在此时间范围内,这些相互作用可能是由于实验开始时已经存在的细胞表面蛋白质所致。正在使用封闭的液体细胞进行长时间的课程研究,以观察合成连接蛋白时相互作用的变化。与先前关于心肌细胞相互作用的研究不同,在对齐和未对齐的胶原蛋白上,心脏成纤维细胞的相互作用之间没有可观察到的差异。但是,需要对定义明确的图案化底物进行进一步研究,以确定胶原蛋白排列是否不影响成纤维细胞相互作用。

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