Efficacy, release profile, and degradation behaviour of PDLLA + Gentamicin Sulphate coating on Ti-6Al-7Nb alloy in PBS

机译：PBS中Ti-6Al-7Nb合金上PDLLA +庆大霉素硫酸盐涂层的功效，释放曲线和降解行为

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The investigated coating of poly(D,L-lactide) and Gentamcin sulphate is fully resorbable, degradation occurs through hydrolytic scission of the chains. The release of the antibiotic occurs in a distinct burst release as could be expected for this highly hydrophilic substance. The amount of released antibiotic and the burst release profile indicate that this coating formulation is appropriate to confront and inhibit initial surface colonization of an orthopedic implant by bacteria in the time immediately following implantation. The subsequent complete resorption of the coating guarantees that no residual antibiotics at low concentrations are left, which may cause a potential risk of selecting or breeding antibiotic resistant strains.

机译：所研究的聚（D，L-丙交酯）和硫酸庆大霉素的涂层是完全可吸收的，降解是通过水解水解链而发生的。如这种高亲水性物质所预期的那样，抗生素的释放以明显的爆发释放发生。释放的抗生素量和爆裂释放曲线表明，这种包衣制剂适合在植入后立即面对并抑制细菌对整形外科植入物的初始表面定植。涂层随后的完全吸收保证了不会残留低浓度的残留抗生素，这可能会导致选择或繁殖抗生素抗性菌株的潜在风险。

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来源
《Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2》|2006年|P.629|共1页
会议地点 PittsburghPA(US)
作者
Andrea Montali; Olaf Jahn; Xinyin Liu;
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作者单位

Synthes GmbH, Eimattstrasse 3, 4436 Oberdorf, Switzerland;

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原文格式 PDF
正文语种 eng
中图分类生物材料学;
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1. Gentamicin sulphate release from a modified commercial acrylic surgical radiopaque bone cement. I. Influence of the gentamicin concentration on the release process mechanism. [J] . Diez Pena E, Frutos G, Frutos P, Chemical and Pharmaceutical Bulletin . 2002,第9期

机译：庆大霉素硫酸盐从改性商业丙烯酸不透射线骨水泥中释放。 I.庆大霉素浓度对释放过程机理的影响。
2. A gentamicin-releasing coating for cementless hip prostheses-longitudinal evaluation of efficacy using in vitro bio-optical imaging and its wide-spectrum antibacterial efficacy [J] . NeutD., DijkstraR.J.B., ThompsonJ.I., Journal of biomedical materials research, Part A . 2012,第12期

机译：用于非骨水泥髋关节假体的庆大霉素释放涂层的纵向生物光学成像评价及其广谱抗菌功效
3. Short and long term degradation behaviour of Mg-1Ca magnesium alloys and protective coatings based on plasma-chemical oxidation and biodegradable polymer coating in synthetic body fluid [J] . P. Rosemann, A. Heyn, J. Schmidt Materials and Corrosion . 2013,第8期

机译：Mg-1Ca镁合金和基于等离子体化学氧化和生物可降解聚合物涂层的防护涂层在合成体液中的短期和长期降解行为
4. Efficacy, release profile, and degradation behaviour of PDLLA + Gentamicin Sulphate coating on Ti-6Al-7Nb alloy in PBS [C] . Andrea Montali, Olaf Jahn, Xinyin Liu Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 . 2006

机译：PBS中Ti-6Al-7Nb合金上PDLLA +庆大霉素硫酸盐涂层的功效，释放曲线和降解行为
5. Behaviour of Ni-Based Coating Alloys in Supercritical Water [D] . Qian, Yunfen 2011

机译：镍基涂层合金在超临界水中的行为
6. The effects of a SiO2 coating on the corrosion parameters cpTi and Ti-6Al-7Nb alloy [O] . Marcin Basiaga, Witold Walke, Zbigniew Paszenda, 2014

机译：SiO2涂层对cpTi和Ti-6Al-7Nb合金腐蚀参数的影响
7. Gentamicin Sulphate Release from a Modified Commercial Acrylic Surgical Radiopaque Bone Cement. I. Influence of the Gentamicin Concentration on the Release Process Mechanism. [O] . Eva Díez-Peña, Gloria Frutos, Paloma Frutos, 2002

机译：庆大霉素硫酸盐从改性的商业丙烯酸外科外透射线骨水泥释放。 I.庆大霉素浓度对释放过程机制的影响。
8. THE INFLUENCE OF SODIUM SULPHATE AND SODIUM CHLORIDE ON THE OXIDATION RESISTANCE OF A Cr-Ti-Si COATING ON ALLOY B66 [R] . E. P. WHELAN, J. M. TRENOUTH 1969

机译：硫酸钠和氯化钠对合金B66上Cr-Ti-si涂层抗氧化性能的影响

Efficacy, release profile, and degradation behaviour of PDLLA + Gentamicin Sulphate coating on Ti-6Al-7Nb alloy in PBS

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