首页> 外文会议>Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2 >Control of Cell-Matrix Interactions on Fibrin Bi-layers and Micro-Patterned Surfaces
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Control of Cell-Matrix Interactions on Fibrin Bi-layers and Micro-Patterned Surfaces

机译:纤维蛋白双层和微图案表面上细胞-基质相互作用的控制。

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Fibrin bi-layers were formed in a stepwise way on SAMs with different terminal groups. It was shown that the difference in the orientation/conformation of the first layer of fibrinogen induced by different surface chemistries lead to fibrin bi-layers with different structures. Fibrin bi-layers with different structures, and thus different mechanochemical properties induced the endothelial cells cultured on them to develop into distinct phenotypes. Furthermore, it was shown for the first time that micro-grooved surfaces can induce the formation of capillary-like structures by endothelial cells.
机译:在具有不同端基的SAM上逐步形成纤维蛋白双层。结果表明,由不同的表面化学诱导的纤维蛋白原第一层的取向/构型的差异导致具有不同结构的纤维蛋白双层。具有不同结构的纤维蛋白双层,因此具有不同的机械化学性质,导致培养在其上的内皮细胞发展为不同的表型。此外,首次表明微沟槽表面可以诱导内皮细胞形成毛细血管状结构。

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