Controlling the Degradation Rate of PEGylated Fibrin Gels for Ceil Delivery

机译：控制用于细胞递送的聚乙二醇化纤维蛋白凝胶的降解速率

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Degradation control and cell viability are core qualities needed for a tunable, biodegradable cell therapy matrix. We have shown that cellular proliferation is increased and the longevity of the gel is increased when using a 10:1 molar ratio of PEG:Fibrinogen. Interestingly, increasing the PEG:Fibrinogen ratio to 100:1 significantly reduces the degradation time. Future studies are necessary to assess the utility of this device as a viable cellular delivery methodology

机译：降解控制和细胞生存能力是可调谐，可生物降解的细胞治疗基质所需的核心品质。我们已经表明，当使用PEG：纤维蛋白原的摩尔比为10：1时，细胞增殖会增加，凝胶的寿命也会增加。有趣的是，将PEG：纤维蛋白原比例提高至100：1可显着减少降解时间。未来的研究是必要的，以评估这种设备作为一种可行的细胞递送方法的实用性

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《Society for Biomaterials Transaction Annual Meeting vol.29 pt.1; 20060426-29; Pittsburgh,PA(US)》|2006年|127|共1页
会议地点 PittsburghPA(US)
作者
S.F. Collins; G. Zhang; J. Zhang; L.J. Suggs;
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University of Texas at Austin;

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原文格式 PDF
正文语种 eng
中图分类生物材料学;
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4. Controlling the Degradation Rate of PEGylated Fibrin Gels for Ceil Delivery [C] . S.F. Collins, G. Zhang, J. Zhang, Society for Biomaterials Transaction Annual Meeting vol.29 pt.1; 20060426-29; Pittsburgh,PA(US) . 2006

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Controlling the Degradation Rate of PEGylated Fibrin Gels for Ceil Delivery

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