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Osseointegration Effect of BMP-2 on Dental Implants: A 3-6 Week In Vivo Study

机译:BMP-2对种植牙的骨整合作用:3-6周体内研究

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Earlier studies have demonstrated the superiority of calcium phosphate as a material component in dental and bone implants when compared to titanium. Thus, the significant difference in osseointegration between the two surface types is not an unexpected result. As an implant surface, plasma-spray treated calcium phosphate exhibited a higher degree of bone-implant contact over that of titanium with more than a 50% increase in the presence of rhBMP-2 at 3 weeks relative to its uncoated counterpart. Our results suggest that the PSCaP implant surface is more amenable to adsorption of bone morphogenic protein for early healing release. For future studies, earlier time points must be considered in order to further investigate the effect of rhBMP-2 on osseointegration in terms of measurable parameters and kinetics.
机译:较早的研究表明,与钛相比,磷酸钙作为牙科和骨植入物中的材料成分具有优越性。因此,两种表面类型之间的骨整合的显着差异并不是意料之外的结果。作为植入物表面,经过等离子体喷涂处理的磷酸钙与钛相比,与钛相比具有更高的骨-植入物接触程度,相对于其未涂覆的对应物,在存在rhBMP-2的情况下,在3周时增加了50%以上。我们的结果表明,PSCaP植入物表面更适合骨形态发生蛋白的吸附,以便早期愈合释放。对于将来的研究,必须考虑更早的时间点,以便根据可测量的参数和动力学进一步研究rhBMP-2对骨整合的影响。

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