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Synergistic effect of sustained release growth factors from PLGA microspheres and dynamic bioreactor flow on hMSC osteogenic differentiation in alginate scaffolds

机译：PLGA微球缓释生长因子和动态生物反应器流量对藻酸盐支架中hMSC成骨分化的协同作用

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The release study showed that SEE is a suitable fabrication method of PLGA microspheres to provide sustained release of growth factors. Also, BMP-2 had a dominant effect on osteogenic marker production compared to VEGF in both static and dynamic conditions, indicating that it is an important growth factor in the differentiation pathway. Hence, dynamic flow culturing environment in the TPS bioreactor and sustained-release growth factors from PLGA microspheres show to have a synergistic effect on osteogenic differentiation of hMSCs. Future studies will include optimization of the BMP-2 dose delivered to hMSCs.

机译：释放研究表明，SEE是PLGA微球的合适制备方法，可提供生长因子的持续释放。而且，在静态和动态条件下，与VEGF相比，BMP-2对成骨标志物的产生都具有显著作用，表明它是分化途径中的重要生长因子。因此，TPS生物反应器中的动态流动培养环境和PLGA微球中的持续释放生长因子显示出对hMSCs成骨分化的协同作用。未来的研究将包括优化递送至hMSC的BMP-2剂量。

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《Society for biomaterials annual meeting and exposition》|2013年|745|共1页
会议地点 Boston MA(US)
作者
Bao-Ngoc B. Nguyen; Giovanna Delia Porta; Ernesto Reverchon; John P. Fisher;
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Fischell Department of Bioengineering University of Maryland;

Dipartimento di Ingegneria Chimica ed Alimentare Universita di Salerno.;

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4. Synergistic effect of sustained release growth factors from PLGA microspheres and dynamic bioreactor flow on hMSC osteogenic differentiation in alginate scaffolds [C] . Bao-Ngoc B. Nguyen, Giovanna Delia Porta, Ernesto Reverchon, Society for biomaterials annual meeting and exposition . 2013

机译：来自PLGA微球的持续释放生长因子的协同作用及藻酸盐支架中HMSC成骨分化对HMSC成骨分化的影响
5. A macro- and micro-designed chitosan-alginate scaffold with sustained growth factor release for chondrogenesis. [D] . Reed, Stephanie M. 2014

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6. Dynamic cultivation with radial flow bioreactor enhances proliferation or differentiation of rat bone marrow cells by fibroblast growth factor or osteogenic differentiation factor [O] . Yuuhei Kanda, Itsurou Nishimura, Toru Sato, 2016

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7. Dynamic cultivation with radial flow bioreactor enhances proliferation or differentiation of rat bone marrow cells by fibroblast growth factor or osteogenic differentiation factor [O] . Kanda Yuuhei, Nishimura Itsurou, Sato Toru, 2016

机译：径向流动生物反应器动态培养通过成纤维细胞生长因子或成骨分化因子促进大鼠骨髓细胞的增殖或分化

Synergistic effect of sustained release growth factors from PLGA microspheres and dynamic bioreactor flow on hMSC osteogenic differentiation in alginate scaffolds

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