首页> 外文会议>Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 >Cell Binding and Cytotoxicity of Palmitic-Acid Modified Polyethylenimine (PEI) and Poly-L-lysine (PLL) on Bone Marrow Stromal Cells (BMSC)
【24h】

Cell Binding and Cytotoxicity of Palmitic-Acid Modified Polyethylenimine (PEI) and Poly-L-lysine (PLL) on Bone Marrow Stromal Cells (BMSC)

机译:棕榈酸修饰的聚乙烯亚胺(PEI)和聚L-赖氨酸(PLL)对骨髓基质细胞(BMSC)的细胞结合和细胞毒性

获取原文

摘要

Modification of the cationic polymers PEI and PLL with hydrophobic side groups increases the binding of the polymers to the cells. Toxicity, in some cases is reduced as a result of PA substitution. Although DNA complexation ability of reduced, the hydrophobic polymers did retain the ability of condensing DNA at higher polymer:DNA ratios. Further studies are warranted to investigate the ability of these polymers to carry DNA intracellularly, and allow expression of genes delivered with a plasmid DNA.
机译:用疏水性侧基修饰阳离子聚合物PEI和PLL可增加聚合物与细胞的结合。由于PA取代,毒性在某些情况下会降低。尽管DNA络合能力降低,但疏水性聚合物的确保留了以较高的聚合物:DNA比值缩合DNA的能力。有必要进行进一步的研究来研究这些聚合物在细胞内携带DNA的能力,并允许表达随质粒DNA传递的基因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号