Aptamer Immobilized Field Effect Transistor for Early Diagnostic of Human Immunodeficiency Virus Type 1 (HIV-1)

机译：适体固定的场效应晶体管，用于早期诊断人类免疫缺陷病毒1型（HIV-1）

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In recent years, aptamer-based biosensors have aroused great interest in detecting different targets, such as proteins, peptides and whole cells. In contrast to antibodies-based biosensors, the selected aptamer can be synthesized with high reproducibility. Also, aptamers are usually chemically stable. In this study, we demonstrated HIV-1 RT-specific aptamers-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) for detecting different concentrations of HIV-1 RT protein ranging from 1 fM to 10 pM in physiological salt concentrations.

机译：近年来，基于适体的生物传感器引起了人们对检测不同目标的兴趣，例如蛋白质，多肽和全细胞。与基于抗体的生物传感器相比，所选的适体可以高重复性合成。同样，适体通常是化学稳定的。在这项研究中，我们展示了固定有HIV-1 RT的适体固定化的AlGaN / GaN高电子迁移率晶体管（HEMT），用于检测生理盐浓度范围从1 fM到10 pM的不同浓度的HIV-1 RT蛋白。

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《Solid-state electronics and photonics in biology and medicine 2》|2015年|25-29|共5页
会议地点 Phoenix AZ(US)
作者
Chia-Ho Chu; Indu Sarangadharan; Abiral Regmi; Yi-Ting Chen; Yu-Lin Wang;
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Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, R.O.C.;

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, R.O.C.;

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, R.O.C.;

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, R.O.C.;

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, R.O.C.;

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1. Performance of the Celera Diagnostics ViroSeq HIV-1 Genotyping System for Sequence-Based Analysis of Diverse Human Immunodeficiency Virus Type 1 Strains [J] . Susan H. Eshleman, John Hackett, Priscilla Swanson, Journal of Clinical Microbiology . 2004,第6期

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2. Field Evaluation of a Combination of Monospecific Enzyme-Linked Immunosorbent Assays for Type-Specific Diagnosis of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 Infections in HIV-Seropositive Persons in Abidjan, Ivory Coast [J] . John N. Nkengasong, Chantal Maurice, Stéphania Koblavi, Journal of Clinical Microbiology . 1998,第1期

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3. Roles of Clinical and Subclinical Reactivated Herpes Simplex Virus Type 2 Infection and Human Immunodeficiency Virus Type 1 (HIV-1)-Induced Immunosuppression on Genital and Plasma HIV-1 Levels. [J] . Mayaud P The Journal of Infectious Diseases . 2008,第2期

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4. Aptamer Immobilized Field Effect Transistor for Early Diagnostic of Human Immunodeficiency Virus Type 1 (HIV-1) [C] . Chia-Ho Chu, Indu Sarangadharan, Abiral Regmi, Meeting of the Electrochemical Society . 2015

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5. Isolation and characterization of RNA aptamers targeted to the aspartyl protease of the human immunodeficiency virus type 1 (HIV-1). [D] . Duclair, Sonald. 2010

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6. Cross-Clade Inhibition of Recombinant Human Immunodeficiency Virus Type 1 (HIV-1) HIV-2 and Simian Immunodeficiency Virus SIVcpz Reverse Transcriptases by RNA Pseudoknot Aptamers [O] . Daniel M. Held, Jay D. Kissel, Sarah J. Thacker, 2007

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8. Guidance for Industry: Nucleic Acid Testing (NAT) for Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis C Virus (HCV): Testing, Product Disposition, and Donor Deferral and Reentry [R] . 2010

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Aptamer Immobilized Field Effect Transistor for Early Diagnostic of Human Immunodeficiency Virus Type 1 (HIV-1)

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