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首页> 外文会议>Speckle 2010: Optical metrology >Towards automatic detection of malignant melanoma by laser speckle
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Towards automatic detection of malignant melanoma by laser speckle

机译：致力于通过激光散斑自动检测恶性黑色素瘤

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摘要

The incidence of malignant melanoma (MM), the most aggressive and deadly form of skin cancer, has been increasing rapidly since the last few decades. Clinical differentiation between MM and pigmented benign skin lesions based on visual assessment can be challenging because some of benign lesions such as melanocytic lesions (ML) and seborrheic keratoses (SK) resemble MM. In this paper we introduce a novel, non-invasive, "optical biopsy" method based on laser speckle. Propagating inside the skin tissues, photons undergo optical path dispersion due to scattering. Therefore the emerging light loses the initial state of coherence, which influences the backscattered speckle pattern if the light optical path deviation in a tissue is comparable with the length of coherence. Speckle contrast is a measure of this decorrelation process. Histology shows that MM, ML, and SK have diverse morphology. We hypothesized that the morphological differences can be detected by polychromatic speckle, and the technique can be used to differentiate these lesions in vivo. In a study with 12 MMs, 24 MLs, and 37 SKs, we computed the speckle contrast related to their superficial skin region. The mean contrast of MM, ML and SK were 0.78 (standard error (SE) = 0.02, 0.63 (SE = 0.01), and 0.67 (SE = 0.01), respectively. Statistical test showed that there was a significant difference among the contrast of the three types of lesions (p < 0.001, Kruskal-Wallis), and intergroup pair-wise tests showed significant differences in distribution between all three groups. Potentially, speckle imaging can differentiate these lesions.
机译：自最近几十年来，恶性黑色素瘤（MM）是皮肤癌中最具侵害性和致命性的一种形式，其发病率一直在迅速增加。基于视觉评估的MM与色素性良性皮肤病变之间的临床区分可能具有挑战性，因为某些良性病变（例如黑素细胞病变（ML）和脂溢性角化病（SK））与MM类似。在本文中，我们介绍了一种基于激光散斑的新颖，非侵入性的“光学活检”方法。光子在皮肤组织内部传播，由于散射而经历了光路色散。因此，出射的光失去了相干的初始状态，如果组织中的光路偏移与相干的长度相当，则该初始状态会影响后向散射斑点图案。斑点对比度是该去相关过程的量度。组织学表明，MM，ML和SK具有多种形态。我们假设多色斑点可以检测到形态学差异，并且该技术可以用于在体内区分这些病变。在一项针对12个MM，24个ML和37个SK的研究中，我们计算了与它们的浅表皮肤区域相关的斑点对比。 MM，ML和SK的平均对比度分别为0.78（标准误（SE）= 0.02、0.63（SE = 0.01）和0.67（SE = 0.01）），统计检验表明，三种类型的病变（p <0.001，Kruskal-Wallis）和组间成对检验显示，三组之间的分布存在显着差异，散斑成像可能会区分这些病变。

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  • 来源
    《Speckle 2010: Optical metrology》|2010年|p.73871D.1-73871D.8|共8页
  • 会议地点 Florianopolis(BR)
  • 作者

    T. K. Lee; L. Tchvialeva; H. Lui; H. Zeng; D. I. McLean;

  • 作者单位

    Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute University of British Columbia, 835 West 10th Ave., Vancouver, BC, Canada,V5Z 4E8 Departments of Cancer Control Research and Cancer Imaging, BC Cancer Research Centre, 675 West 10th Ave., Vancouver, BC, Canada, V5Z 1L3 School of Computing Science, Simon Fraser University, 8888 University Drive, Burnaby, BC,Canada, V5A 1S6;

    Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute University of British Columbia, 835 West 10th Ave., Vancouver, BC, Canada,V5Z 4E8;

    Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute University of British Columbia, 835 West 10th Ave., Vancouver, BC, Canada,V5Z 4E8 Departments of Cancer Control Research and Cancer Imaging, BC Cancer Research Centre, 675 West 10th Ave., Vancouver, BC, Canada, V5Z 1L3;

    Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute University of British Columbia, 835 West 10th Ave., Vancouver, BC, Canada,V5Z 4E8 Departments of Cancer Control Research and Cancer Imaging, BC Cancer Research Centre, 675 West 10th Ave., Vancouver, BC, Canada, V5Z 1L3;

    Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute University of British Columbia, 835 West 10th Ave., Vancouver, BC, Canada,V5Z 4E8;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光学计量;
  • 关键词

    Polychromatic speckle contrast; skin cancer; malignant melanoma; melanocytic lesions; seborrheic keratoses non-invasive biopsy; optical biopsy;

    机译：多色斑点对比；皮肤癌;恶性黑色素瘤黑素细胞病变脂溢性角化病的非侵入性活检；光学活检;

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