• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>STP 1471; Symposium on Titanium, Niobium, Zirconium, and Tantalum for Medical and Surgical Applications; 20051109-10; Washington,DC(US) >Zirconium and Niobium Affect Human Osteoblasts, Fibroblasts, and Lymphocytes in a Similar Manner to More Traditional Implant Alloy Metals
【24h】

Zirconium and Niobium Affect Human Osteoblasts, Fibroblasts, and Lymphocytes in a Similar Manner to More Traditional Implant Alloy Metals

机译：锆和铌影响人类成骨细胞，成纤维细胞和淋巴细胞的方式与更传统的植入合金金属相似

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Implant debris remains the major factor limiting the longevity of total joint replacements. Whether soluble implant debris of Zr and Nb containing implant alloys constitute a greater risk than other implant metals remains unknown. We evaluated the relative effects of soluble forms of Zr+4 and Nb+5 (0.001-10.0 mM) relative to Cr+3, Mo+5, Al+3, Co+2, Ni+2 , Fe+3, Cu+2, Mn+2, Mg+2, Na+2, and V+3 chloride solutions on human peri-implant cells (i.e., osteoblast-like MG-63 cells, fibroblasts, and lymphocytes). Metals were ranked using a 50% decrease in proliferation and viability to determine toxic concentrations. Lymphocytes, fibroblasts, and osteoblasts were, generally, similarly affected by metals where the most toxic metals, Co, Ni, Nb, and V required < 1.0 mM to induce toxicity. Less toxic metals Al, Cr, Fe, Mo, and Zr generally required > 1.0 mM challenge to produce toxicity. Overall, Co and V were the most toxic metals tested, thus Zr and Nb containing implant alloys would not likely be more toxic than traditional implant alloys. Below concentrations of 0.1 mM, neither Zr nor Nb reduced osteoblast, lymphocyte, or fibroblast proliferation. Zr was generally an order of magnitude less toxic than Nb to lymphocytes, fibroblasts, and osteoblasts. Our results indicated that soluble Zr and Nb resulting from implant degradation likely act in a metal- and concentration-specific manner capable of producing adverse local and remote tissue responses to the same degree as metals from traditional implant alloys, e.g., Ti-6Al-4V (ASTM F 138) and Co-Cr-Mo alloys (ASTM F 75).
机译：植入物碎片仍然是限制全关节置换物寿命的主要因素。含Zr和Nb的植入合金的可溶性植入物碎片是否比其他植入物金属构成更大的风险仍然未知。我们评估了Zr + 4和Nb + 5（0.001-10.0 mM）可溶性形式相对于Cr + 3，Mo + 5，Al + 3，Co + 2，Ni + 2，Fe + 3，Cu +的相对影响图2中的Mn + 2，Mg + 2，Na + 2和V + 3氯化物溶液在人体植入物周围的细胞（即成骨细胞样MG-63细胞，成纤维细胞和淋巴细胞）上。使用增殖和生存力降低50％来对金属进行排名，以确定毒性浓度。淋巴细胞，成纤维细胞和成骨细胞通常同样受到金属的影响，其中毒性最高的金属Co，Ni，Nb和V需要<1.0 mM才能诱发毒性。毒性较低的金属Al，Cr，Fe，Mo和Zr通常要求> 1.0 mM挑战才能产生毒性。总体而言，Co和V是测试毒性最高的金属，因此含Zr和Nb的植入合金的毒性可能不会比传统的植入合金高。低于0.1 mM的浓度，Zr和Nb均不会减少成骨细胞，淋巴细胞或成纤维细胞的增殖。通常，Zr对淋巴细胞，成纤维细胞和成骨细胞的毒性比Nb低一个数量级。我们的结果表明，由植入物降解引起的可溶性Zr和Nb可能以金属和浓度特定的方式起作用，能够产生不利的局部和远端组织反应，其程度与传统植入物合金（例如Ti-6Al-4V）的金属相同（ASTM F 138）和Co-Cr-Mo合金（ASTM F 75）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号