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首页> 外文会议>Symposium Proceedings vol.915; Symposium on Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications; 20060418-20; San Francisco,CA(US) >Silicon MicroChannel Array as a Basis of Biosensor Device
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Silicon MicroChannel Array as a Basis of Biosensor Device

机译：硅微通道阵列作为生物传感器设备的基础

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摘要

This work shows the possibilities of using the silicon-based microchannel array (Si-MCA) as a 3D-solid support of DNA probes and studying of application of optical methods for DNA hybridization direct analysis. It was obtained that amount of immobilized oligodeoxyribonucleotides on the Si-MCA surface is enhanced with lighting of Si-MCA microchannel. The sample of 160 μm thickness succeeded in immobilizing oligonucleotides 40 times as much as the standard glass slides having the same external surface. The application of Si-MCA as a carrier of DNA allows doing direct analysis of nucleic acids in infrared region by the FTIR method that essentially simplifies creation of a biosensor based on the Si-MCA. It is indicated that using of the Si-MCA as a diffraction grating in visible and UV spectra allows simplifying the spectral analysis of biochemical reaction. It was success confidently to distinguish the mediums differing on the refractive index by △=0.006.
机译：这项工作表明使用基于硅的微通道阵列（Si-MCA）作为DNA探针的3D固体支持物以及研究光学方法进行DNA杂交直接分析的可能性。得到的结果是，通过点亮Si-MCA微通道，可以提高Si-MCA表面上固定的寡脱氧核糖核苷酸的量。厚度为160μm的样品成功固定了寡核苷酸，是具有相同外表面的标准载玻片的40倍。 Si-MCA作为DNA载体的应用允许通过FTIR方法对红外区域的核酸进行直接分析，该方法从根本上简化了基于Si-MCA的生物传感器的创建。表明在可见光谱和UV光谱中使用Si-MCA作为衍射光栅可以简化生化反应的光谱分析。可以可靠地分辨出折射率相差△= 0.006的介质。

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