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首页> 外文会议>Symposium on Rapid Prototyping Technologies Dec 3-5, 2002 Boston, Massachusetts, U.S.A. >A Process to Make Collagen Scaffolds with an Artificial Circulatory System using Rapid Prototyping
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A Process to Make Collagen Scaffolds with an Artificial Circulatory System using Rapid Prototyping

机译：使用快速原型的人工循环系统制造胶原蛋白支架的过程

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Tissue engineering aims to produce biological substitutes to restore or repair damaged human tissues or organs. The principle strategy behind tissue engineering involves seeding relevant cell(s) onto porous 3D biodegradable scaffolds. The scaffold acts as a temporary substrate where the cells can attach and then proliferate and differentiate. Collagen is the major protein constituent of the extracellular matrix in the human body and therefore an attractive scaffold material. Current collagen scaffolds are foams which limit the mass transport of oxygen and nutrients deep into the scaffold, and consequently cannot support the growth of thick-cross sections of tissue (greater than 500 μm). We have developed a novel process to make collagen and collagen-hydroxyapatite scaffolds containing an internal artificial circulatory system in the form of branching channels using a sacrificial mould, casting and critical point drying technique. The mould is made using a commercial rapid prototyping system, the Model-Maker E, and is designed to possess a series of connected shafts. The mould is dissolved away and the solvent itself removed by critical point drying with liquid carbon dioxide. Processed hydroxyapatite has been characterised by XRD and FTIR analysis. Tissue engineering with collagen scaffolds possessing controlled internal microarchitecture may be the key to growing thick cross-sections of human tissue.
机译：组织工程旨在生产生物替代品，以恢复或修复受损的人体组织或器官。组织工程背后的原理策略涉及将相关细胞接种到多孔3D可生物降解的支架上。支架充当细胞可以附着然后增殖和分化的临时底物。胶原蛋白是人体细胞外基质的主要蛋白质成分，因此是一种有吸引力的支架材料。当前的胶原蛋白支架是泡沫，其限制氧气和营养物深入支架中的质量传递，因此不能支持组织的厚横截面（大于500μm）的生长。我们已经开发出一种新的工艺来制作胶原蛋白和胶原蛋白-羟基磷灰石支架，该支架采用牺牲模具，浇铸和临界点干燥技术，以分支通道的形式包含内部人工循环系统。模具使用商业快速原型制作系统Model-Maker E制成，并设计为具有一系列相连的轴。将模具溶解掉，并通过用液态二氧化碳进行临界点干燥除去溶剂本身。通过XRD和FTIR分析表征了加工的羟基磷灰石。具有受控的内部微结构的胶原蛋白支架的组织工程可能是增长人体组织的厚截面的关键。

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