Specific Interactions of Glass Fibers with Extracellular Matrix Proteins

机译：玻璃纤维与细胞外基质蛋白的特异性相互作用

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When inhaled glass fibers reach the alveolar tissue, primary interfacial phenomena would be expected to occur between these fibers and the extracellular matrix (ECM) of the alveolar cells. We have developed a microscale in vitro system to identify and characterize ECM proteins adsorbed to the surface of these fibers. Preliminary studies have focused o nthree fiber types: MMVF 10 (rapidly dissolving borosilicate), MMVF 34 (high alumina HT), and RCF 1 (approx 50:50 alumina:silica). Adherent ECM proteins stripped from the fibers represented a subset of ECM proteins. While most of the adsorbed proteins were common to all fiber types, some differnecess in protein profiles were observed. In several cases the amount of protein adsorbed to the fiber appeared significnatly enhanced over the amount of the same protein in the ECM. These data suggest that the fiber surfaces had high affinity for some ECM. These data suggest that the fiber surfaces had high affinity for some ECM proteins. Numerous adsorbed proteins were in the low molecular weight range which includes growth factors, hormones, and signal molecules involved in both tissue inflammatory and healing responses.

机译：当吸入的玻璃纤维到达肺泡组织时，预计在这些纤维与肺泡细胞的细胞外基质（ECM）之间会发生主要的界面现象。我们已经开发出一种微型体外系统，以鉴定和表征吸附到这些纤维表面的ECM蛋白。初步研究集中于三种纤维类型：MMVF 10（快速溶解硼硅酸盐），MMVF 34（高氧化铝HT）和RCF 1（约50:50氧化铝：二氧化硅）。从纤维上剥离的粘附性ECM蛋白代表了ECM蛋白的一个子集。虽然大多数吸附的蛋白质是所有纤维类型所共有的，但观察到蛋白质谱存在一些差异。在某些情况下，与ECM中相同蛋白质的数量相比，吸附到纤维上的蛋白质数量明显增加。这些数据表明纤维表面对某些ECM具有高亲和力。这些数据表明纤维表面对某些ECM蛋白具有高亲和力。许多吸附的蛋白质都处于低分子量范围内，包括生长因子，激素和参与组织炎症和愈合反应的信号分子。

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《Symposium on Surface-Active Process in Materials, Cocoa Beach, Florida, January 25-29, 1999》|1999年|p.231-239|共9页
会议地点 Cocoa Beach FL(US)
作者
Alan H.Goldstein; Joel S.Salesky;
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正文语种 eng
中图分类一般工业技术;
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Specific Interactions of Glass Fibers with Extracellular Matrix Proteins

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