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首页> 外文会议>Therapeutic laser applications and laser-tissue interactions IV >Femtosecond-Lentotomy Treatment: Six Month Follow Up of in vivo treated Rabbit Lenses
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Femtosecond-Lentotomy Treatment: Six Month Follow Up of in vivo treated Rabbit Lenses

机译：飞秒-宫颈切开术治疗：体内治疗兔晶状体的六个月随访

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Presbyopia is an age related effect which affects every human at the age of about 40 years. So far reading glasses are the conventional treatment. According to Helmholtz' theory of accommodation one of the mayor reasons for the development of presbyopia is the increasing sclerosis of the lens. In contrast to that the ciliary muscle and the lens capsule remain mostly active and elastic the whole life. So a possible treatment could be the increase of the flexibility of the lens by creating gliding planes with fs-laser pulses inside the lens tissue.rnIn former studies it was shown that fs-laser pulses were able to increase the flexibility of ex vivo porcine lenses as well as ex vivo human donor lenses. Our current aim was to evaluate the effect of the fs-laser pulses on the crystalline lens of living rabbit eyes due to the fs-lentotomy treatment. The main focus of the evaluation was the exclusion of possible side effects of the treatment like cataract formation or retina damage. The treated eyes were monitored using optical coherence tomography (OCT) and Scheimpflug imaging for localizing and studying the tissue effects of the incisions. Furthermore histological sections of the lens and retina were prepared. The rabbits were investigated pre operatively and up to six months post operatively.rnThe fs-laser induced micro incisions were successfully applied to the left lens of each rabbit. The micro incisions within the crystalline lens were detectable with OCT and Scheimpflug imaging up to six month. The imaging within the lens showed a progressive fading of the ineisional opacities generated by the femtosecond laser during the six months and no indication of cataract formation was found. OCT and Scheimpflug images emphasize themselves as necessary tools to monitor the micro incisions over time. Histopathological sections of the lens tissue support the findings of the non invasive imaging techniques. Also the histopathological sections of the retina show no thermal induced change due to the irradiation of the fs-pulses.
机译：老花眼是一种与年龄有关的效应，会影响每个40岁左右的人。迄今为止，老花镜是常规治疗。根据Helmholtz的适应理论，老花眼发展的市长原因之一是晶状体硬化程度的增加。与之相反的是，睫状肌和晶状体囊在整个生命过程中大多保持活跃并富有弹性。因此，可能的治疗方法是通过在晶状体组织内部创建带有fs-激光脉冲的滑动面来增加晶状体的柔韧性。rn以前的研究表明，fs-激光脉冲能够提高离体猪晶状体的柔韧性。以及离体人类供体镜片。我们目前的目的是评估由于fs切开术治疗而导致的fs激光脉冲对活兔眼晶状体的影响。评估的主要重点是排除可能的副作用，如白内障形成或视网膜损伤。使用光学相干断层扫描（OCT）和Scheimpflug成像监测治疗的眼睛，以定位和研究切口的组织效应。此外，准备了晶状体和视网膜的组织学切片。在手术前和手术后六个月对兔子进行了检查。将fs-激光诱导的微切口成功地应用于每只兔子的左晶状体。使用OCT和Scheimpflug成像可以检测到晶状体中的微切口，最多可以检测六个月。晶状体内部的成像显示在六个月内飞秒激光产生的非透明混浊逐渐消失，没有发现白内障形成的迹象。 OCT和Scheimpflug图像将自己强调为监测随时间变化的微切口的必要工具。晶状体组织的组织病理学切片支持无创成像技术的发现。视网膜的组织病理学切片也没有显示出由于fs脉冲的照射而引起的热诱导变化。

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