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首页> 外文会议>The Third China-Korea conference on separation science and technology >Colloidal Adsorption of Bovine Serum Albumin on Porous Polypropylene-g-Poly(2-hydroxyethyl methacrylate) Membrane
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Colloidal Adsorption of Bovine Serum Albumin on Porous Polypropylene-g-Poly(2-hydroxyethyl methacrylate) Membrane

机译：牛血清白蛋白在多孔聚丙烯-g-聚（甲基丙烯酸2-羟乙酯）膜上的胶体吸附

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摘要

To understand the effects of protein adsorption on the filtration performance, poly(2-hydroxyethyl methacrylate) (PHEMA) was grafted by the γ-ray pre-irradiation process onto the porous surface of polypropylene (PP) membrane. The colloidal filtration of such membranes was discussed with respect to the correlation between the adsorption of the BSA proteins and the variation of physical properties of the PP-graft-PHEMA (PP-g-PHEMA) membrane surface. The specific resistance (α_c) of protein layer formed during filtration was obtained by line fitting through the filtration experimental result, using the colloidal filtration model proposed by Carman. The existence of PHEMA gave much faster rates of permeation than the original PP membrane due to the more or less dilute BSA protein concentration at PHEMA layer. It was confirmed from the filtration experiment that the PHEMA layer grafted on the surface of membrane attributed the prevention of the intimate contact of BSA proteins from the surface of membrane, resulting in a low specific resistance due to the increase of interspacing of protein layer composed of the BSA protein particles. Especially, α_c of 40.6wt% PHEMA layer is 0.72·10~2 (m~(-1)g~(-1)), much lower than that of the unmodified original PP membrane (α_c: 6.24·10~2).
机译：为了了解蛋白质吸附对过滤性能的影响，通过γ射线预辐照工艺将聚甲基丙烯酸2-羟乙酯（PHEMA）接枝到了聚丙烯（PP）膜的多孔表面上。关于BSA蛋白质的吸附与PP-接枝-PHEMA（PP-g-PHEMA）膜表面的物理性质的变化之间的相关性，讨论了这种膜​​的胶体过滤。使用Carman提出的胶体过滤模型，通过过滤实验结果通过线拟合获得了过滤过程中形成的蛋白质层的电阻率（α_c）。由于PHEMA层的BSA蛋白质浓度稀少，PHEMA的存在使渗透速率比原始PP膜快得多。从过滤实验中证实，嫁接在膜表面的PHEMA层有助于防止BSA蛋白与膜表面的紧密接触，由于增加了由BSA蛋白组成的蛋白层之间的间距，导致电阻率低BSA蛋白颗粒。特别是，PHEMA层为40.6wt％的α_c为0.72·10〜2（m〜（-1）g〜（-1）），远低于未改性的原始PP膜的α_c（α_c：6.24·10〜2）。

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