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首页> 外文会议>Ultrasonic Imaging and Signal Processing; Progress in Biomedical Optics and Imaging; vol.8,no.32; Proceedings of SPIE-The International Society for Optical Engineering; vol.6513 >A new sonographic method for the evaluation of skin permeability changes after irradiation with low-frequency ultrasound
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A new sonographic method for the evaluation of skin permeability changes after irradiation with low-frequency ultrasound

机译：评价低频超声照射后皮肤通透性变化的超声检查新方法

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摘要

The irradiation of the skin with low-frequency ultrasound (42 MHz) increases the skin permeability, allowing the US stimulated drug delivery (sonophoresis). The changes in the skin permeability is generally demonstrated with the measurement of corneometry and transepidermal water loss (TEWL). A novel ultrasound scanner with a 50 MHz probe was used for acquiring images of the skin (penetration depth few millimeters). The images show the different epidermal and dermis layers. A specially designed plexiglas basin containing an US transducer was used. Water was used as matching medium. The transducer was set to generate a 42 MHz continuous wave US beam with an intensity of 150 mW/cm2 for a chosen preset time. Ninety healthy volunteers were submitted to exposure of the back of the hand. The back of the hand of each person was scanned at 50 MHz before the irradiation and after 1,15 and 60 minutes. A significant variation of the stratum corneum and the derma on the sonographic image was found. A particular software code was developed in order to quantify the amount of the variation in the image, using different parameters (entropy, energy, skewness, kurtosis, etc.) related to the pixel value in different regions of interest and to the cumulated profile along lines perpendicular to the skin surface. The variations in the parameters so defined were demonstrated to be statistically significant and with a sensibility much higher than corneometry and TEWL. This new approach allow to better understand the mechanism and quantify the changes in the skin permeability.
机译：低频超声（42 MHz）对皮肤的照射增加了皮肤的通透性，从而使US刺激了药物的递送（超声渗透）。皮肤渗透性的变化通常通过角膜测定法和表皮失水量（TEWL）来证明。使用具有50 MHz探头的新型超声波扫描仪来获取皮肤图像（穿透深度为几毫米）。图像显示了不同的表皮和真皮层。使用了包含美国换能器的特殊设计的有机玻璃盆。水用作匹配介质。将传感器设置为在选定的预设时间内产生强度为150 mW / cm2的42 MHz连续波US光束。 90名健康志愿者接受了手背的暴露。在照射之前以及在1,15和60分钟之后，以50 MHz扫描每个人的手背。在超声图像上发现角质层和皮肤的显着变化。开发了一个特定的软件代码，以便使用与感兴趣的不同区域中的像素值相关的不同参数（熵，能量，偏度，峰度等）来量化图像中的变化量，并沿着垂直于皮肤表面的线条。如此定义的参数变化被证明具有统计学显着性，并且其敏感性远高于角测角法和TEWL。这种新方法可以更好地了解其机理并量化皮肤渗透性的变化。

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