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首页> 外文会议>Workshop on Macro, Trace and Ultratrace Elements; 20040924-25; Jena(DE) >Comparison of lipase, acyltransferase triacylglycerol: cholesterol activities and levels of copper and zinc in serum of men and women patients with coronary heart disease
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Comparison of lipase, acyltransferase triacylglycerol: cholesterol activities and levels of copper and zinc in serum of men and women patients with coronary heart disease

机译：脂肪酶，酰基转移酶三酰基甘油的比较：男女冠心病患者胆固醇的活动以及血清铜和锌的含量

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It is known that zinc (Zn) and copper (Cu) can affect the cholesterol esters biosynthesis and lipid concentrations in patients with atherosclerosis. Since gender differences in plasma lipid profile as risk factors for CHD are recognized, therefore the aim of this study was to compare the serum Zn, Cu levels, lipid profile, lipase (GEH) and acyltransferase triacylglycerol : cholesterol (GECAT) activities between men and woman with CHD. The subjects of the study were 21 male and 18 female outpatients with CHD. The levels of triacylglycerols (TAG), total cholesterol (TC), low (LDL-C) and high density lipoprotein-cholesterol (HDL-C), apolipoprotein A and B (Apo-A and Apo-B), and the enzyme (GECAT, GEH) activities were assayed by methods ascribed elsewhere (Patelski and Piorunska-Stolzmann 1979). Zn and Cu levels were determined by using an atomic absorption spectrometry (Iskra et al. 1997). The lowering TAG and HDL-C with a concurrent rise in Apo-A levels of women were found, when compared with men group. Sex of patients did not affect the GEH and GECAT activities. The higher Cu was assayed in women when compared with men, whereas Zn levels did not differ. The negative correlations between Cu and TAG were found in woman. Moreover, the strong correlation coefficient between Zn and GECAT but only in woman was observed. In conclusion, the role of these elements should be taken into consideration in evaluating the cholesterol transacylation process in serum of patients, especially women with CHD.
机译：众所周知，锌（Zn）和铜（Cu）会影响动脉粥样硬化患者的胆固醇酯生物合成和脂质浓度。由于人们认识到血浆脂质谱的性别差异是冠心病的危险因素，因此本研究的目的是比较男性和女性之间的血清锌，铜水平，脂质谱，脂肪酶（GEH）和酰基转移酶三酰基甘油：胆固醇（GECAT）的活性。冠心病的年轻女子。该研究的受试者为21名男性和18名女性冠心病患者。三酰甘油（TAG），总胆固醇（TC），低（LDL-C）和高密度脂蛋白胆固醇（HDL-C），载脂蛋白A和B（Apo-A和Apo-B）以及酶（ GECAT，GEH）的活性用别处提到的方法测定（Patelski和Piorunska-Stolzmann 1979）。锌和铜的含量通过原子吸收光谱法测定（Iskra等，1997）。与男性相比，发现女性的TAG和HDL-C降低，同时Apo-A水平升高。患者的性别不影响GEH和GECAT活动。与男性相比，女性的铜含量更高，而锌的含量没有差异。在女性中发现Cu和TAG之间的负相关。此外，观察到Zn与GECAT之间的强相关系数，但仅在女性中。总之，在评估患者（尤其是冠心病女性）血清中的胆固醇转酰化过程时，应考虑这些元素的作用。

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