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Benefits/Effectiveness of Pulmonary Surfactant Therapy in Neonatal Respiratory Distress Syndrome:A Case Report and Literature Review

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目录

Abbreviations

英文摘要

Neonatal Respiratory Distress Syndrome.

History of Pulmonary Surfactant Therapy.

Synthesis of Endogenous Pulmonary Surfactant

Composition of Pulmonary Surfactant

Function of Pulmonary Surfactant

Pulmonary Surfactant Preparations

Comparison of High and low dose natural surfactants.

Earlier surfactant treatment policy.

Benefits of Exogenous Pulmonary Surfactant Therapy in NRDS

Timing of surfactant

Pulmonary Surfactant Usage

Surfactant in other neonatal lung disease

A CASE REPORT

Summary

Conclusion

参考文献

致谢

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摘要

Neonatal Respiratory distress syndrome (NRDS), is an acute lung disease of the newborn caused by surfactant deficiency. It is one of the most common causes of respiratory failures in premature babies, especially in neonates younger than 32 weeks' gestational age and weighing less than 1200 g. Ventilation was used to improve oxygenation and diseased mortality of neonates with NRDS, but it may cause severe lung injury including pneumothorax, ventilator-associated pneumonia and increase the incidence of chronic lung disease or bronchopulmonary dysplasia, intracranial hemorrhage. Surfactant therapy became available in the 1980s and has significantly changed clinical practice in neonatology over the last 30 years. Early postnatal Surfactant therapy has been shown to improve oxygenation, decrease air leaks, and most importantly decreases infant mortality from NRDS.
  The purpose of this review is to give an overview the developments in field of pulmonary surfactant, focusing on benefits of surfactant replacement therapy in preterm NRDS, reported a case with NRDS managed with an extract of porcine lung surfactant.

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