Enzyme Triggered Carriers Based on Cyclodextrin Anchored Hollow Mesoporous Silica for Enhancing Insecticidal Activity of Chlorantraniliprole and Avermectin Against Plutella Xylostella

声明

CONTENTS

Abstract

摘要

List of Abbreviations

Chapter 1．LITERATURE REVIEW

1 Introduction

1．1 Drug-delivery

1．2 Drug-carriers

1．3 Pesticides controlled release formulation

1．4 Silica-based nano-carriers’ role in drug-delivery

1．5 Porous silica nanoparticles role in pesticides formulation

1．6 Porous silica nanoparticles surface functionalization

1．7 The selected pesticides

Chapter 2．Synthesis of three different sizes of Hollow mesoporous silica carriers for controlled release of pesticides

1 Introduction

2 Materials and Characterization

2．1 Materials

2．2 Characterization

3 Methods

3．1 Synthesis of CRFs

3．2 HMS surface functionalization

3．3 Loading cargo molecules and sealing HMS pores

4 CRFS characterization

4．1 CRFs thermal and light stability assay

4．2 Release figuration from CRFs under various stresses

4．3 Staffstical analysis of controlled release data

4．4 Assay of biological activities of pesticides-CRFs

5 Results

5．1 CRF fabrication

5．2 TEM and SEM observations

5．3 Fourier transmission infrared spectroscopy

5．4 N2 adsorption-desorption isotherms

5．5 Dynamic light scattering(DLS)

5．6 Drug loading efficiency(DLE)

5．7 Thermal and light stability of CLAP-CRFs and AVM-CRFs

5．8 CLAP-CRF and AVM-CRF controlled release kinetics

5．9 CRFs biological activity

Summary

References

Appendixes

Publications

Acknowledgements