非洲撒哈拉以南地区轮状病毒疫苗的有效性：系统综述和Meta分析

ACKNOWLEDGEMENT

声明

ABSTRACT

摘要

TABLE OF CONTENTS

LIST OF FIGURES

LIST OF TABLES

LIST OF ACRONYMS

CHAPTER ONE：INTRODUCTION

1．1 Background of Research

1．2 Problem Statement

1．3 Aims and Objectives

1．4 Organization of Thesis

CHAPTER TWO：LITERATURE REVIEW

2．1．1 Types of Rotavirus

2．1．2 Structure

2．1．3 Proteins

2．1．4 Structural Proteins

2．1．5 Replication

2．2．1 Signs and Symptoms

2．2．2 Transmission

2．2．3 Disease Mechanisms

2．2．4 Diagnosis and Detection

2．2．5 Treatment and Prognosis

2．3．Current trend of rotavirus infection

2．4．Rotavirus Vaccine

3．1 Literature Search

3．2 Inclusion Criteria and exclusion criteria

3．3 Data Abstraction

3．5 Statistical Analysis

CHAPTER 4：EXPERIMENTAL RESULTS AND DISCUSSION

4．1．1 Characteristics of the Included Studies

4．1．2 Effectiveness Results of RVA Vaccines in US

4．2．Meta-Analysis of Rotavirus Effectiveness in Sub-Saharan Africa

4．2．1 Characteristics of the Included Studies for sub-Sahara Afpica

4．2．2 Effectiveness Results of RVA Vaccines in Sub-Saharan Africa

4．3．Test for Publication Bias

4．4．Discussion

CHAPTER 5：CONCLUSION AND RECOMMENDATION

5．1 Conclusion

5．2 Reconlmendations and Future Work

REFERENCES

Appendices