声明
Chapter 1. Introduction
1.1 Photothmal therapy
1.1.1 Introduction of the photothermal therapy
1.1.2 Photothermal agents
1.2 Photodynamic therapy
1.2.1 Introduction of photodynamic therapy
1.2.2 The photosensitizers of photodynamic therapy
1.3 Multi-model imaging technologies for cancer therapy
1.3.1 Conventional single-modal imaging
1.3.2 Multi-modal imaging
1.4 Project design
Chapter 2. Polymer-based gadolinium oxide nanocomposites for FL/MR/PA imaging guided and photothermal/photodynamic combined anti-tumor therapy
2.1 Brief introduction
2.2Materials and methods
2.2.1 Experimentalmaterials and equipments
2.2.2 Preparation of Gd2O3@PPy-HA
2.2.3 Characterization of nanoparticels
2.2.4 Drug loading and release
2.2.5 Measurement of photothermal performance
2.2.6 Singlet oxygen generation detection
2.2.7 In vitro cellular studies
2.2.8 In vivo animal experiments
2.3 Results and discussion
2.3.1 Preparation of Gd2O3@PPy/AlPc-HA nanoparticles
2.3.2 Characterization of Gd2O3@PPy/AlPc-HA nanoparticles
2.3.3 Drug Release
2.3.4 Detection of extracellular ROS
2.3.5 Measurement of photothermal performance
2.3.6 In vitro imaging study
2.3.7 In vitro Cellular studies
2.3.8 In vivo animal studies
2.4 Brief summary
Chapter 3. GSH-mediated Clearable Nanoparticles Based on Ultra-small Gd2O3 for MSOT/CT/MR Imaging Guided Photothermal/Radio Combination Cancer Therapy
3.1 Brief introduction
3. 2 Materials and methods
3.2.1 Experimentalmaterials and equipments
3.2.2 Preparation of Gd2O3/BSA@MoS2-HA
3.2.3 Characterization of nanoparticles
3.2.4 In vitro Photothermal Performance
3.2.5 Hemolysis Assay
3.2.6 In vitro cellular studies
3.2.7 Multi-modal imaging
3.2.8 Structural Degradation and excretion study
3.2.9 In vivo animal experiments
3.3 Results and discussion
3.3.1 Preparation of Gd2O3/BSA@MoS2-HA nanoparticles
3.3.2 Characterization of Gd2O3/BSA@MoS2-HA
3.3.4 Measurement of photothermal performance
3.3.5 In vitro imaging study
3.3.6 In vitro Cellular studies
3.3.7 In vivo animal studies
3.4 Brief summary
Chapter 4. Conclusion and prospect
4.1 Conclusion
4.2 Prospect
参考文献
Notes on publications and participation in scientific research
致谢
天津大学;
