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Combinatorial and high-throughput methods for biomaterials synthesis and design.

机译：生物材料合成和设计的组合和高通量方法。

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摘要

Combinatorial strategies have been developed to study the phase behavior of biodegradable polyanhydrides for drug and protein delivery applications. The polyanhydrides of interest are poly[1,6-bis(p-carboxyphenoxy) hexane] (CPH) and poly[sebacic anhydride] (SA). Both continuous and discrete polymer blend libraries were fabricated by using a combination of solution-based gradient deposition and rapid prototyping. Blend compositions were characterized via a unique high throughput transmission mode FTIR sampling technique and compared against theoretical mass balance predictions. To obtain phase diagrams of CPH/SA, the effect of blend composition and annealing temperature on the miscibility of the blend was studied. This gradient library was observed with optical microscopy in order to determine cloud points. These results were compared with SAXS studies on discrete libraries, which contained previously specified blend compositions and the agreement between the two methods was very good. The CPH/SA system exhibits upper critical solution temperature behavior.
机译：已开发出组合策略来研究可生物降解的聚酸酐在药物和蛋白质递送应用中的相行为。感兴趣的聚酐是聚[1,6-双（对羧基苯氧基）己烷]（CPH）和聚[癸二酸酐]（SA）。连续和离散聚合物共混物库都是通过结合使用基于溶液的梯度沉积和快速原型制造而成的。共混物的成分通过独特的高通量传输模式FTIR采样技术进行了表征，并与理论质量平衡预测进行了比较。为了获得CPH / SA的相图，研究了共混物的组成和退火温度对共混物混溶性的影响。用光学显微镜观察该梯度库以确定浊点。将这些结果与离散库中的SAXS研究进行比较，该库包含先前指定的共混物组成，两种方法之间的一致性很好。 CPH / SA系统显示出较高的临界溶液温度行为。

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  • 作者

    Thorstenson, Jon Brian.;

  • 作者单位

    Iowa State University.$bChemical and Biological Engineering.;

  • 授予单位 Iowa State University.$bChemical and Biological Engineering.;
  • 学科 Engineering Chemical.
  • 学位 M.S.
  • 年度 2007
  • 页码 95 p.
  • 总页数 95
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化工过程（物理过程及物理化学过程）;
  • 关键词

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