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首页> 外文学位 >Image registration and statistical analysis for quantitative in vivo spin-lock magnetic resonance imaging of the intervertebral disc response to compression.
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Image registration and statistical analysis for quantitative in vivo spin-lock magnetic resonance imaging of the intervertebral disc response to compression.

机译：椎间盘对压缩反应的定量体内自旋锁磁共振成像的图像配准和统计分析。

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Low back pain decreases the quality of life and affects almost 50% of the population. Quantitative spin-lock magnetic resonance imaging of the T 1rho, relaxation parameter is a promising marker of early degeneration in intervertebral discs. However, T1rho measurements may be affected by disc compression, and understanding this effect is necessary for studying abnormal dynamics of disc response to compression or correlations between degeneration and T1rho values.; We developed an algorithm to register images of intervertebral discs in different compression states and to calculate the statistical significance of local changes in T1rho. Our procedure includes automatic registration during image acquisition to view the some location across exams, segmentation of intervertebral discs with minimal user intervention, automatic registration of discs using a non-rigid transformation guided by rigid transformations of vertebrae, and a method of investigating the statistical significance of changes in local neighborhoods using resampling hypothesis testing with variable confidence levels.; Validation tests on phantoms and volunteer data indicate sub-pixel registration accuracy and precision. Registration results agree with a manual gold standard. Hypothesis testing is sensitive to registration accuracy, indicating the need for registration even with patient movements of less than a millimeter. Tests confirm expected trade-offs between type I and type II statistical significance errors depending on neighborhood size, significance level, and confidence level.; We demonstrate the algorithm on varying compression states caused by lying down after 30 minutes of standing with a 20 lb backpack or by supporting 55 pounds while lying using a leg-press-like device. T1rho varies locally depending on the distribution of compression within the discs. The coefficient of variation was 7.6% while relaxing and 13.9% when applying and releasing the compression device, indicating an effect of the device. Variation was 48% less in degenerated versus healthy discs (p 0.04). T1rho in the lower discs increased by 20% (p 0.05) when the compression device pressure was released. Local comparisons showed that T1rho tended to decrease under compression and increase after compression was released. Changes were not significant during an hour of supine resting, suggesting that variable pre-scan compression from normal daily activities does not considerably complicate T1rho measurements.
机译：下背痛会降低生活质量，并影响近50％的人口。 T 1rho的定量自旋锁磁共振成像，弛豫参数是椎间盘早期变性的有希望的标志。然而，T1rho测量值可能会受到椎间盘压缩的影响，因此了解这种影响对于研究椎间盘对压缩的异常动态或变性与T1rho值之间的相关性是必要的。我们开发了一种算法，可以记录处于不同压缩状态的椎间盘图像，并计算T1rho局部变化的统计显着性。我们的程序包括在图像采集过程中自动注册以查看检查中的某些位置，以最小的用户干预对椎间盘进行分割，使用由椎骨的刚性变换引导的非刚性变换自动对光盘进行注册以及调查统计意义的方法使用具有可变置信度的重采样假设检验来评估本地社区的变化。对体模和志愿者数据的验证测试表明亚像素配准的准确性和准确性。注册结果符合人工金标准。假设检验对套准精度很敏感，表明即使患者运动小于一毫米也需要套准。测试证实了I型和II型统计显着性误差之间的预期权衡，具体取决于邻域大小，显着性水平和置信度。我们演示了在20磅背包站立30分钟后躺下或使用类似腿部按压的设备躺下55磅后所造成的不同压缩状态的算法。 T1rho根据光盘中压缩的分布而局部变化。松弛时的变异系数为7.6％，使用和释放压缩装置时的变异系数为13.9％，表明该装置的效果。与健康椎间盘相比，变性椎间盘的差异要小48％（p <0.04）。释放压缩装置压力后，下部椎间盘中的T1rho增加20％（p <0.05）。局部比较表明，T1rho在压缩下趋于降低，在释放压缩后趋于增加。仰卧休息一个小时内变化不显着，表明正常日常活动产生的可变的预扫描压缩不会显着增加T1rho测量的复杂度。

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