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Three-dimensional ultrasound imaging and its applications in combined near-infrared optical imaging and co-registered photoacoustic imaging.

机译：三维超声成像及其在近红外光学成像和共配准光声成像中的应用。

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摘要

This dissertation focuses on three-dimensional (3-D) ultrasound and its applications as an adjunct modality for biomedical optical imaging.; Near infrared diffusive optical tomography (NIR-DOT) has demonstrated outstanding functional imaging potential, especially in breast cancer detection. Due to the high scattering of light in tissue, however, it suffers from poor spatial localization. Ultrasound has the capability to provide accurate geometric information and excellent spatial resolution. We have therefore combined NIR and ultrasound imaging to take advantage of both methodologies. A 64-channel linear array ultrasound imaging system has been developed and integrated with a NIR-DOT system to provide registered a priori lesion information of lesion to guide the optical reconstruction. Clinical applications benefit from three-dimensional localization of tumors and for this purpose a 1280-channel volumetric-scanning ultrasound system has been developed using a 1.75D array. 1.75D acoustic arrays are well suited for this application due to their ability to scan volumes rapidly and accurately while maintaining a reasonable system complexity and cost. Simulations of the system performance in terms of resolution, transmission/reception patterns, and field of view have been performed and confirmed with experimental measurements.; Photoacoustic (PAT) imaging is another promising non-invasive imaging technology due to its ability to combine the enhanced contrast of optical absorption with the spatial resolution of acoustic imaging. Co-registration of ultrasound and photoacoustic images takes advantage of both modalities to allow simultaneous visualization of tissue structural and functional information. The developed 1.75D ultrasound system has been characterized for photoacoustic operation and compared with theoretical and simulation predictions. Co-registered images of various phantom targets have been successfully obtained, demonstrating excellent potential for clinical applications.
机译：本文主要研究三维（3-D）超声及其作为生物医学光学成像的辅助手段的应用。近红外扩散光学层析成像（NIR-DOT）已显示出出色的功能成像潜力，尤其是在乳腺癌检测中。但是，由于光在组织中的高度散射，因此其空间定位较差。超声波具有提供准确的几何信息和出色的空间分辨率的能力。因此，我们将近红外和超声成像相结合，以利用两种方法的优势。已开发出64通道线性阵列超声成像系统，并将其与NIR-DOT系统集成在一起，以提供病变的已登记先验病变信息，以指导光学重建。临床应用受益于肿瘤的三维定位，为此目的，已使用1.75D阵列开发了1280通道容积扫描超声系统。 1.75D声学阵列由于能够快速而准确地扫描体积，同时又保持合理的系统复杂性和成本，因此非常适合该应用。在分辨率，发射/接收模式和视野方面对系统性能进行了仿真，并通过实验测量得到证实。光声（PAT）成像是另一种有前途的无创成像技术，因为它能够将增强的光吸收对比度与声成像的空间分辨率结合在一起。超声和光声图像的共配准利用两种方式的优势，可以同时可视化组织结构和功能信息。已开发的1.75D超声系统已针对光声操作进行了表征，并与理论和仿真预测进行了比较。已成功获得各种幻影靶标的共同配准图像，证明了其在临床应用中的巨大潜力。

著录项

  • 作者

    Guo, Puyun.;

  • 作者单位

    University of Connecticut.;

  • 授予单位 University of Connecticut.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 114 p.
  • 总页数 114
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

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