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首页> 外文学位 >The association of overweight with allergy and asthma in children: Findings from the National Health and Nutrition Examination Survey (NHANES) 1999--2006.
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The association of overweight with allergy and asthma in children: Findings from the National Health and Nutrition Examination Survey (NHANES) 1999--2006.

机译：儿童超重与过敏和哮喘的关联：1999--2006年美国国家健康和营养检查调查（NHANES）的发现。

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摘要

Obesity and asthma prevalence have both risen among children over the last several decades, and research efforts increasingly suggest that obesity is associated with asthma. Atopy is a strong risk factor for asthma, but previous literature on the relationship between obesity and atopy has been inconsistent. In addition, some, but not all, studies have shown that the effect of obesity on asthma is stronger among non-atopic individuals than among those with atopy. Systemic inflammation may be a factor in the relationship between obesity and asthma. Breastfeeding may potentially protect against obesity, atopy, and asthma.;This dissertation used National Health and Nutrition Examination and Survey (NHANES) data from 1999-2006 to examine the relationship between obesity and asthma among U.S. children age 2-19. Data from 2005-2006, which include assays for total and allergen-specific IgE, were used to explore the relationship of obesity with IgE levels, atopy, and allergy symptoms, and also to stratify the obesity-asthma analysis by atopic status. The protective effect of breastfeeding was investigated using data for children age 1-6.;Obese children were more likely to report having current asthma than children of normal weight (OR: 1.68, 95% CI: 1.33, 2.12). The association did not differ by gender, but was stronger among non-atopic children than among children with at least 1 positive specific IgE result (OR: 2.46, 95% CI: 1.21, 5.02 vs. OR: 1.34, 95% CI: 0.70, 2.57; interaction p-value 0.09). Total IgE levels increased with BMI in a dose response manner and the odds of having at least one positive specific IgE were elevated among obese children compared to normal weight children (OR: 1.35; 95% CI: 1.04-1.76). C-reactive protein levels were associated with both atopy and asthma, and may indicate a role for systemic inflammation for both outcomes. Breastfeeding was found to protect against obesity and asthma, but not atopy. The protective effect of breastfeeding against asthma was not modified by obesity or by atopy.;An increased risk of allergic disease and asthma may not be the most consequential health risk faced by overweight children. Nonetheless, it provides additional motivation for undertaking the difficult challenge to reduce childhood obesity.
机译：在过去的几十年中，儿童的肥胖症和哮喘患病率均上升，研究工作越来越表明肥胖症与哮喘有关。特应性是哮喘的重要危险因素，但有关肥胖与特应性之间关系的先前文献并不一致。此外，一些（但不是全部）研究表明，非特应性个体中肥胖对哮喘的影响要强于特应性个体。全身性炎症可能是肥胖与哮喘之间关系的一个因素。母乳喂养可能会预防肥胖，特应性疾病和哮喘。本论文使用了美国国家健康和营养检查与调查（NHANES）1999-2006年的数据来检验肥胖与哮喘在美国2-19岁儿童中的关系。 2005-2006年的数据包括总和过敏原特异性IgE的测定，用于探讨肥胖与IgE水平，特应性和过敏症状的关系，并通过特应性状态对肥胖-哮喘进行分层。使用1-6岁儿童的数据调查了母乳喂养的保护作用。肥胖儿童比正常体重儿童更有可能报告患有哮喘（OR：1.68，95％CI：1.33，2.12）。这种关联没有性别差异，但是在非特应性儿童中比在至少1个IgE特异性阳性结果儿童中更强（OR：2.46，95％CI：1.21，5.02，而OR：1.34，95％CI：0.70 ，2.57；互动p值0.09）。与正常体重的儿童相比，肥胖儿童的总IgE水平随BMI的增加而呈剂量反应方式，并且至少有一种阳性特异性IgE的几率增加了（OR：1.35; 95％CI：1.04-1.76）。 C反应蛋白水平与特应性和哮喘相关，并且可能表明这两种结局均与全身性炎症有关。发现母乳喂养可以预防肥胖和哮喘，但不能预防特应性。肥胖或特应性并未改变母乳喂养对哮喘的保护作用。过敏性疾病和哮喘的风险增加可能不是超重儿童面临的最重要的健康风险。尽管如此，它为减少儿童肥胖的艰巨挑战提供了额外的动力。

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  • 作者

    Visness, Cynthia M.;

  • 作者单位

    The University of North Carolina at Chapel Hill.;

  • 授予单位 The University of North Carolina at Chapel Hill.;
  • 学科 Epidemiology.;Public health.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 148 p.
  • 总页数 148
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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