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Exposure to loud noise and risk of acoustic neuroma.

机译：暴露于大声噪音和听觉神经瘤的风险中。

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摘要

This dissertation presents three related investigations that evaluate the previously reported association between loud noise exposure and the risk of acoustic neuromas, as well as the proposed biological basis for the association. The goal of the first investigation was to examine further the role of loud noise in acoustic neuroma etiology. In a population-based case-control study conducted from 1999-2002 in Sweden, reports of occupational and nonoccupational loud noise exposure of 146 acoustic neuroma cases and 564 controls were compared. Individuals reporting loud noise exposure from any source were found to be at increased risk for acoustic neuromas. The findings of an increased risk of acoustic neuromas with loud noise exposure support previous research.;The goal of the second investigation was to further examine the association between noise exposure and acoustic neuroma using an objective measure of exposure. A total of 793 acoustic neuroma cases were identified between 1987 and 1999 from the Swedish Cancer Registry, to which 101,756 controls were frequency matched. Occupational information, available for 599 of the cases and 73,432 of the controls, was obtained from censuses and linked to a job exposure matrix. Of three studies of noise exposure and acoustic neuroma risk to date, this is the first to use a job exposure matrix to assess exposure. Contrary to previous study results the findings do not demonstrate an increased acoustic neuroma risk related to occupational noise exposure.;A mechanism of acoustic neuroma tumorigenesis during the cellular repair process following acoustic trauma has been proposed, whereby cellular division results in DNA replication errors which may in turn lead to chromosomal changes essential for neoplastic transformation. In the third investigation, an extensive literature search was conducted to evaluate the biological plausibility of this hypothesis. The tumor typically involves the vestibular rather than the acoustic division of the eighth nerve, however intralabyrinthine and cochlear nerve schwannomas have been reported. Additionally, evidence of vestibular damage in rodents has been demonstrated following acoustic trauma. The proposed hypothesis is therefore plausible, however further research is needed to elucidate the precise biological basis for the association between loud noise and acoustic neuromas.
机译：本论文提出了三项相关研究，以评估先前报道的大声噪声暴露与听觉神经瘤风险之间的关联，以及所提出的关联的生物学基础。首次研究的目的是进一步研究大声噪声在听神经瘤病因中的作用。在瑞典从1999年至2002年进行的一项基于人群的病例对照研究中，比较了146例听神经瘤病例和564例对照的职业性和非职业性大声噪声暴露报告。发现报告来自任何来源的巨大噪音暴露的个体患听觉神经瘤的风险增加。噪声暴露导致听觉神经瘤风险增加的发现支持先前的研究。第二项研究的目的是使用客观的暴露度量进一步检查噪声暴露与听觉神经瘤之间的关联。在1987年至1999年之间，瑞典癌症登记处共鉴定出793例听神经瘤病例，其中101,756例对照与之频率匹配。可从普查中获得599例病例和73,432例对照的职业信息，并将其与工作暴露矩阵关联。迄今为止，在三项关于噪声暴露和听神经瘤风险的研究中，这是第一个使用工作暴露矩阵评估暴露的研究。与先前的研究结果相反，该发现并未证明与职业性噪声暴露有关的听神经瘤风险增加。；已经提出了在听觉创伤后的细胞修复过程中听神经瘤发生的机制，其中细胞分裂导致DNA复制错误，可能是反过来会导致肿瘤转化所必需的染色体改变。在第三次调查中，进行了广泛的文献检索，以评估该假设的生物学合理性。肿瘤通常累及第八神经的前庭而不是听觉上的分裂，但是已经报道了迷路内和耳蜗神经神经鞘瘤。另外，在听觉创伤后已经证明了啮齿动物前庭损伤的证据。因此，提出的假设是合理的，但是需要进一步研究以阐明大声噪声与听神经瘤之间关联的精确生物学基础。

著录项

  • 作者

    Edwards, Colin G.;

  • 作者单位

    The Ohio State University.;

  • 授予单位 The Ohio State University.;
  • 学科 Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 140 p.
  • 总页数 140
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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