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首页> 外文学位 >Improving global monitoring of vaccine safety: An evaluation of the World Health Organization Programme for International Drug Monitoring and Adverse Reactions Database on how they serve the needs of vaccine safety.
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Improving global monitoring of vaccine safety: An evaluation of the World Health Organization Programme for International Drug Monitoring and Adverse Reactions Database on how they serve the needs of vaccine safety.

机译：改进疫苗安全性的全球监测：对世界卫生组织国际药物监测和不良反应数据库计划的评估，说明它们如何满足疫苗安全性需求。

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摘要

The World Health Organization (WHO) Programme for International Drug Monitoring (PIDM) was developed for chemical rather than biological products. The ability of the PIDM to meet the needs of vaccine safety is of international public health importance. Three studies were conducted: (1) a survey of authorities responsible for reporting adverse events following immunizations (AEFIs); (2) an analysis of the WHO Adverse Reactions Database; and (3) a systematic review to identify and compare Bayesian methods used in drug and vaccine signaling. Communication between national surveillance authorities and lack of vaccine-specific terminologies are issues of concern. Many AEFI reports are not forwarded to the PIDM, and reporting timeliness and regularity should be improved. Few studies have examined the use of Bayesian methods in vaccine signaling. Vaccines should be recognized as a distinct group of drugs. Additional staff dedicated to AEFI reporting and vaccine signaling would be a valuable asset to the PIDM.
机译：世界卫生组织（WHO）的国际药物监测计划（PIDM）是针对化学产品而非生物产品而开发的。马存保机构满足疫苗安全需求的能力具有国际公共卫生重要性。进行了三项研究：（1）对负责报告免疫后不良事件（AEFI）的当局进行调查； （2）对世卫组织不良反应数据库的分析； （3）进行系统评价，以鉴定和比较用于药物和疫苗信号传递的贝叶斯方法。国家监督当局之间的交流和缺乏疫苗专用术语是令人关注的问题。许多AEFI报告没有转发给PIDM，因此报告的及时性和规律性应该得到改善。很少有研究检查疫苗信号中贝叶斯方法的使用。疫苗应被视为不同种类的药物。负责AEFI报告和疫苗信号的额外人员将是马存保机构的宝贵资产。

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  • 作者

    Letourneau, Megan A.;

  • 作者单位

    University of Ottawa (Canada).;

  • 授予单位 University of Ottawa (Canada).;
  • 学科 Health Sciences Medicine and Surgery.;Health Sciences Health Care Management.
  • 学位 M.Sc.
  • 年度 2007
  • 页码 158 p.
  • 总页数 158
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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