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首页> 外文学位 >Arginine and fetal growth in ovine models of intrauterine growth restriction.
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Arginine and fetal growth in ovine models of intrauterine growth restriction.

机译：绵羊精氨酸和胎儿生长对子宫内生长的限制。

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摘要

This research was conducted to test the hypothesis that parenteral arginine supplementation is effective in enhancing birth weights of intrauterine growth restricted (IUGR) fetuses. Underfed and prolific ewes were used as experimental models. The first study characterized the pharmacokinetics of arginine and citrulline and assessed the potential of citrulline to serve as a precursor for enhancing arginine availability in fetal and maternal plasma. Six late pregnant ewes and their fetuses were instrumented to access arterial and venous circulations. Intravenous boluses of 155 mumol of L-arginine-HCl or L-citrulline per kg body weight were administered to each ewe. Administration of citrulline was more effective than arginine in achieving a sustained increase in concentrations of arginine in maternal and fetal blood. Accordingly, the clearance rate of citrulline was lower and its biological half-life in maternal blood greater, when compared with arginine. The second experiment determined if administration of arginine to underfed ewes is effective in ameliorating or preventing IUGR. Ewes were fed either 100% or 50% of the National Research Council recommended nutrient requirements for pregnant sheep. Between Day 60 of pregnancy and parturition control-fed ewes received saline solution and underfed ewes received either saline solution or L-arginine-HCl solution (155 mumol of arginine/kg body weight) intravenously three times daily (n=5/treatment group). Birth weights of lambs were lower in saline-infused underfed ewes. There was no difference in birth weights of lambs from control-fed and arginine-treated underfed ewes. The third experiment determined whether administration of arginine could improve survival rates of lambs and enhance fetal growth in ewes carrying multiple fetuses. Between Days 100 and 121 of pregnancy, ewes received an intravenous infusion of either saline solution (n=14) or L-arginine-HCl solution (345 mumol of arginine/kg body weight, n=20) three times daily. Parenteral administration of arginine increased the percentage of lambs born alive and enhanced the birth weights of quadruplets. Collectively, these results indicate that (1) parenteral administration of arginine improves pregnancy outcomes in underfed and prolific ewes; and (2) the use of arginine or citrulline may have important implications for the design of an effective treatment for preventing or ameliorating IUGR in mammals.
机译：进行这项研究以检验以下假设：肠胃外补充精氨酸可有效增加宫内生长受限（IUGR）胎儿的出生体重。饲喂不足和多产的母羊用作实验模型。第一项研究表征了精氨酸和瓜氨酸的药代动力学，并评估了瓜氨酸作为增强胎儿和母体血浆中精氨酸利用率的前体的潜力。六晚怀孕的母羊和他们的胎儿被用来进入动脉和静脉循环。向每只母羊施用每公斤体重155μmol的L-精氨酸-HCl或L-瓜氨酸的静脉推注。瓜氨酸的施用比精氨酸更有效地实现了母体和胎儿血液中精氨酸浓度的持续增加。因此，与精氨酸相比，瓜氨酸的清除率较低，其在母体血液中的生物学半衰期较长。第二个实验确定了向饲喂不足的母羊施用精氨酸是否可有效改善或预防IUGR。母羊饲喂了美国国家研究委员会（National Research Council）建议的怀孕绵羊所需营养的100％或50％。在怀孕和分娩第60天之间，对照喂养的母羊每天静脉注射3次（n = 5 /治疗组），喂食的母羊接受盐溶液或L-精氨酸-HCl溶液（155摩尔精氨酸/千克体重）静脉注射（n = 5 /治疗组） 。在注入盐水的母羊中，羔羊的出生体重较低。对照饲喂和精氨酸饲喂的饲喂不足的母羊的羔羊出生体重没有差异。第三个实验确定了精氨酸的施用是否可以提高带有多个胎儿的母羊的成年羔羊存活率并促进胎儿生长。在怀孕的第100天至第121天之间，母羊每天接受三次静脉内输注盐溶液（n = 14）或L-精氨酸-HCl溶液（345μmol精氨酸/ kg体重，n = 20）。肠胃外施用精氨酸可增加活产羔羊的百分比，并增加四足动物的出生体重。总体而言，这些结果表明：（1）肠胃外给予精氨酸可改善饲喂不足和多产的母羊的妊娠结局； （2）精氨酸或瓜氨酸的使用可能对设计预防或改善哺乳动物IUGR的有效治疗方法具有重要意义。

著录项

  • 作者

    Lassala, Arantzatzu L.;

  • 作者单位

    Texas A&M University.;

  • 授予单位 Texas A&M University.;
  • 学科 Agriculture Animal Culture and Nutrition.;Biology Veterinary Science.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 119 p.
  • 总页数 119
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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