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Short-term mammary blood flow responses to changes in circulating metabolite concentrations.

机译:短期乳腺血流对循环代谢物浓度变化的反应。

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摘要

Mammary blood flow (MBF) is locally regulated to match nutrient delivery with demands for milk synthesis. The objective of this experiment was to determine which of the major milk precursors would elicit a MBF response when its concentration was elevated in the arterial supply, and to define the time-course of such a response. Treatments of saline (0.38 g/min), glucose (2.2 g/min), amino acids (complete milk protein profile 2.11 g/min), triacylglycerol (Liposyn(TM) 2.0 & 0.87 g/min), insulin (20 ug/min), or adenosine (3 mg/min), were infused into an external iliac arterial catheter for two periods of 20 minutes. Iliac plasma flow dropped 5, 7, and 25 percent within the first minute of infusion of amino acids, glucose and triglyceride, respectively. Adenosine, a known vasodilator, increased plasma flow by 40% immediately upon infusion, to a maximum of 65%, and quickly returned to baseline values upon cessation of treatment. These results indicate that the mammary gland modifies its blood flow rate within seconds of being exposed to new concentrations of milk precursors and is sensitive to circulating levels of adenosine.
机译:乳血流量(MBF)在当地得到了调节,以使营养输送与牛奶合成的需求相匹配。该实验的目的是确定当动脉供血中MBF浓度升高时,哪些主要乳前体会引发MBF反应,并确定这种反应的时间过程。盐水(0.38 g / min),葡萄糖(2.2 g / min),氨基酸(完整的牛奶蛋白质谱2.11 g / min),三酰基甘油(LiposynTM 2.0&0.87 g / min),胰岛素(20 ug /分钟)或腺苷(3毫克/分钟)被注入到外动脉导管中,持续20分钟的两个阶段。在注入氨基酸,葡萄糖和甘油三酸酯的第一分钟内,lia血浆流量分别下降了5%,7%和25%。腺苷(一种已知的血管扩张剂)在输注后立即使血浆流量增加40%,最高可达到65%,并在停止治疗后迅速恢复至基线值。这些结果表明,乳腺在暴露于新浓度的牛奶前体后几秒钟内就会改变其血液流速,并且对腺苷的循环水平敏感。

著录项

  • 作者单位

    University of Guelph (Canada).;

  • 授予单位 University of Guelph (Canada).;
  • 学科 Biology Animal Physiology.
  • 学位 M.Sc.
  • 年度 2006
  • 页码 99 p.
  • 总页数 99
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;
  • 关键词

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