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A simulation-based study of distribution strategies for pharmaceutical supply chains.

机译：基于模拟的药品供应链分销策略研究。

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摘要

This thesis studies the impact of direct-ship distribution strategies in pharmaceutical supply chains. The typical supply chain for branded prescription pharmaceuticals consists of manufacturers, wholesalers, and pharmacies. A direct-ship strategy, also known as disintermediation, entails shipping directly to customers and is under consideration in the pharmaceutical industry. A direct-ship strategy can encompass partial or complete disintermediation of wholesalers, both of which have been successful in other industries. The goal of this work is to determine the impact of different operating policies and degrees of disintermediation on pharmaceutical supply chains. Four direct-ship models with varying levels of disintermediation are compared. The operating policy under consideration is the frequency of deliveries to direct-ship customers. A simulation model is constructed to represent a pharmaceutical supply chain and two and a half years of distribution data was collected from an industry collaborator. The results show that a significantly lower total cost can be achieved with a hybrid strategy that sends 55% of volume directly to customers that operate their own distribution centers and customers that meet minimum value/quantity requirements. With this hybrid strategy, certain product groups see a reduction in standard deviation of inventory and maximum inventory level. For any direct-ship strategy, the operating policy is found to have no impact on total cost at the base case transportation:inventory cost ratio in which inventory cost dominates. Also, no changes to service level performance measures are observed. Sensitivity analysis of the transportation:inventory cost ratio, truck utilization, and product portfolio parameters determines if and at what point the best direct-ship distribution strategy changes.
机译：本文研究了直接配送策略对药品供应链的影响。品牌处方药的典型供应链包括制造商，批发商和药房。直接运输策略（也称为“非中间化”）需要直接运送给客户，并且在制药行业中正在考虑中。直销战略可以包括批发商的部分或完全脱媒，这两者在其他行业都已成功。这项工作的目的是确定不同的运营政策和脱媒程度对药品供应链的影响。比较了四种具有不同解中介水平的直接运输模型。正在考虑的运营政策是直接运送给客户的频率。构建了一个代表药品供应链的仿真模型，并从一个行业合作者那里收集了两年半的分销数据。结果表明，采用混合策略可直接将55％的数量直接发送给运营自己的配送中心的客户以及满足最低价值/数量要求的客户，从而可以大大降低总成本。通过这种混合策略，某些产品组的库存标准偏差和最大库存水平降低了。对于任何直接运输策略，发现在基本情况下，运输策略对总成本没有影响：运输成本：库存成本占主导地位的比率。此外，未观察到服务级别性能指标的变化。运输的敏感性分析：库存成本比率，卡车利用率和产品组合参数决定了最佳直接配送策略是否在何时以及何时改变。

著录项

  • 作者

    Niziolek, Lisa.;

  • 作者单位

    Purdue University.;

  • 授予单位 Purdue University.;
  • 学科 Engineering Industrial.
  • 学位 M.S.I.E.
  • 年度 2008
  • 页码 86 p.
  • 总页数 86
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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