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首页> 外文学位 >A molecular basis for body plan evolution: Insights from the starlet sea anemone, Nematostella vectensis, an anthozoan cnidarian.
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A molecular basis for body plan evolution: Insights from the starlet sea anemone, Nematostella vectensis, an anthozoan cnidarian.

机译：人体计划进化的分子基础：来自小花海葵，线虫线虫（Nematostella vectensis）的花粉症。

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摘要

Recent molecular analyses suggest the cnidarians (corals, sea anemones, and "jellyfish") may be the sister group to the bilaterians, yet traditionally, cnidarians are classified as lacking the synapomorphies that unite the Bilateria (triploblasty, bilateral symmetry, and a centralized nervous system (CNS)). Cnidarians belong to a group of organisms commonly referred to as the Radiata, and are diploblastic (lacking mesoderm), radially symmetric, and lack a CNS, possessing a diffuse nerve net instead. The genome of N. vectensis , the starlet sea anemone, an anthozoan cnidarian, has been sequenced, and represents the first publicly available non-bilaterian, metazoan genome, providing a unique opportunity to investigate the molecular basis for body plan evolution outside of the Bilateria. Utilizing the available N. vectensis genome sequence, I have isolated and characterized the spatial and temporal expression of many of the developmental regulatory and signaling pathway genes that have been implicated in establishing germ layer identity, symmetry properties, and nervous system organization in bilaterians, including members of the Transforming Growth Factor beta (TGFbeta) pathway, their antagonists, the Pax family of transcription factors, and the Fibroblast Growth Factor pathway (FGF). Expression data suggests that N. vectensis utilizes these conserved signaling pathways to establish germ layer identity and a bilaterally symmetric body plan at the molecular level, and possibly organize a regionalized nervous system, suggesting that the ancestor of cnidarians and bilaterians may have been much more complicated that previously thought.
机译：最近的分子分析表明，刺胞鱼（珊瑚，海葵和“水母”）可能是双边生物的姊妹群，但是传统上，刺胞鱼被归类为缺乏团结贝拉里特的突触（三叶类，双侧对称和集中神经系统（CNS））。爬虫类动物属于通常被称为辐射体的一组生物，它们是双叶的（缺乏中胚层），呈放射状对称，并且缺乏中枢神经系统，而是具有弥散的神经网络。 Nectus vectensis的基因组已被测序，它是一种小花海葵，是一种拟人化的刺胞动物，它是第一个可公开获得的非双性后生动物的基因组，为研究在Bilateria以外的人体计划进化的分子基础提供了独特的机会。利用可用的N. vectensis基因组序列，我已经分离并表征了许多发育调节和信号通路基因的时空表达，这些基因与建立双语者的细菌层身份，对称性和神经系统组织有关，包括转化生长因子β（TGFbeta）途径的成员，其拮抗剂，转录因子的Pax家族和成纤维细胞生长因子途径（FGF）。表达数据表明，N。vectensis利用这些保守的信号通路在分子水平上建立了细菌层身份和双边对称的身体计划，并可能组织了一个区域化的神经系统，这表明刺胞和双侧猿的祖先可能更为复杂。以前认为。

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  • 作者

    Matus, David Q.;

  • 作者单位

    University of Hawai'i at Manoa.;

  • 授予单位 University of Hawai'i at Manoa.;
  • 学科 Biology Molecular.; Biology Zoology.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 294 p.
  • 总页数 294
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子遗传学;动物学;
  • 关键词

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