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Thoracic cancer imaging with PET/CT in radiation oncology.

机译：在放射肿瘤学中使用PET / CT进行胸癌成像。

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摘要

Significance. Respiratory motion has been shown to cause artifacts in PET/CT imaging. This breathing artifact can have a significant impact on PET quantification and it can lead to large uncertainties when using PET for radiation therapy planning. We have demonstrated a promising solution to resolve the breathing artifact by acquiring respiration-averaged CT (ACT) for PET/CT. The purpose of this work was to optimize the ACT acquisition for clinical implementation and to evaluate the impact of ACT on PET/CT quantification. The hypothesis was that ACT is an effective method in removing the breathing artifact when compared to our current clinical protocol.; Methods. Phase and cine approaches for acquiring ACT were investigated and the results of these two approaches were compared to the ACT generated from clinical 4DCT data sets (abbreviated as ACT10phs ). In the phase approach, ACT was generated based on combinations of selected respiratory phases; in the cine approach, ACT was generated based on cine images acquired over a fixed cine duration. The phase combination and cine duration that best approximated the ACT10phs were determined to be the optimized scanning parameters. 216 thoracic PET/CT patients were scanned with both current clinical and the ACT protocols. The effects of ACT on PET/CT quantification were assessed by comparing clinical PET/CT and ACT PET/CT using 3 metrics: PET/CT image alignment, maximum standardized uptake value (SUVmax), and threshold segmented gross tumor volume (GTV).; Results. ACT10phs can be best approximated to within 2% of SUV variation by phase averaging based on 4 representative phases, and to within 3% by cine image averaging based on >3s of cine duration. We implemented the cine approach on the PET/CT scanners and acquired 216 patient data sets. 68% of patients had breathing artifacts in their clinical PET/CT and the artifacts were removed/reduced in all corresponding ACT PET/CT. PET/CT quantification for lesions 50 cm3 and located below the dome of the diaphragm was affected the most by the artifact.; Conclusions. We have shown that ACT is an effective method for minimizing respiration artifact in PET/CT. The removal of the artifact significantly changed the SUVmax in 10% of the patients and substantially affected the segmented GTV.
机译：意义。呼吸运动已显示在PET / CT成像中引起伪影。这种呼吸伪影可能会对PET定量产生重大影响，并且在将PET用于放射治疗计划时会导致很大的不确定性。我们已经展示了一种有前途的解决方案，可以通过获取PET / CT的呼吸平均CT（ACT）来解决呼吸伪影。这项工作的目的是为临床实施优化ACT采集，并评估ACT对PET / CT定量的影响。假设是，与我们目前的临床方案相比，ACT是去除呼吸伪影的有效方法。方法。研究了获取ACT的阶段和电影方法，并将这两种方法的结果与从临床4DCT数据集（缩写为ACT10phs）生成的ACT进行了比较。在阶段方法中，根据所选呼吸阶段的组合生成了ACT。在电影方法中，ACT是基于在固定电影持续时间内获取的电影图像生成的。确定最接近ACT10phs的相组合和放映时间是最优化的扫描参数。 216例胸部PET / CT患者接受了当前的临床和ACT方案扫描。通过比较临床PET / CT和ACT PET / CT的3个指标，评估ACT对PET / CT的影响：PET / CT图像对齐，最大标准化摄取值（SUVmax）和阈值分割总肿瘤体积（GTV）。 ;结果。通过基于4个代表性相位的相位平均，可以最佳地将ACT10phs近似于SUV变化的2％以内，通过基于3秒钟以上的电影持续时间的电影图像平均，可以将ACT10phs最佳地近似于3％。我们在PET / CT扫描仪上实施了电影方法，并获取了216个患者数据集。 68％的患者在其临床PET / CT中有呼吸伪影，并且在所有相应的ACT PET / CT中伪影均已消除/减少。小于50 cm3且位于the膜穹lesions下方的病变的PET / CT定量受伪影影响最大。结论。我们已经表明，ACT是使PET / CT中的呼吸伪影最小化的有效方法。去除伪影显着改变了10％的患者的SUVmax，并严重影响了分段的GTV。

著录项

  • 作者

    Chi, Pai-Chun Melinda.;

  • 作者单位

    The University of Texas Graduate School of Biomedical Sciences at Houston.;

  • 授予单位 The University of Texas Graduate School of Biomedical Sciences at Houston.;
  • 学科 Physics Radiation.; Biophysics Medical.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 99 p.
  • 总页数 99
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 原子核物理学、高能物理学;生物物理学;
  • 关键词

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