Porcine mucosal vaccination against foot-and-mouth disease virus.

机译：针对口蹄疫病毒的猪粘膜疫苗接种。

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This dissertation describes the work performed, primarily for the development of a porcine mucosal vaccine against Foot-and-mouth disease virus. Here we evaluate different peptide based vaccines as well as different adjuvants for their capacity to induce both systemic, as well as mucosal immunity in swine, when administered intransally. We also attempt to describe a method of vaccine design based on driving immune responses away from epitopes responsible for type-specificity, and towards more conserved viral epitopes. In the work we determine that peptide vaccination coadministered with adjuvants through the intranasal route of swine, can induce effective anti-peptide responses. We also determine that detoxified mucosal adjuvants, with reduced or abrogated ADP ribosylation activity are capable of adjuvanting immune responses similar to native holotoxins. Finally we show that driving immune responses towards sub-dominant epitopes is possible through substitutions of the type-specific, immunodominant epitopes.

机译：本论文描述了所进行的工作，主要用于开发针对口蹄疫病毒的猪粘膜疫苗。在这里，我们评估不同的基于肽的疫苗以及不同的佐剂，当它们经鼻给药时，既能诱导猪的全身免疫又能诱导粘膜免疫。我们还尝试描述一种基于驱动免疫应答从负责表型特异性的表位向更保守的病毒表位转移的疫苗设计方法。在这项工作中，我们确定通过猪的鼻内途径与佐剂共同施用的肽疫苗可以诱导有效的抗肽反应。我们还确定排毒的粘膜佐剂，具有减少或废除的ADP核糖基化活性，能够佐剂类似于天然全毒素的免疫反应。最后，我们表明，通过替代类型特异性，免疫优势表位，可以朝着亚优势表位推动免疫反应。

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作者
Barrette, Roger William, II.;
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作者单位

University of Connecticut.;

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授予单位 University of Connecticut.;
学科 Agriculture Animal Pathology.; Biology Veterinary Science.
学位 Ph.D.
年度 2007
页码 145 p.
总页数 145
原文格式 PDF
正文语种 eng
中图分类动物医学（兽医学）;动物学;
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1. Enhanced mucosal immune response in cattle persistently infected with foot-and-mouth disease virus. [J] . Mohan MS, Gajendragad MR, Kishore S, Veterinary Immunology and Immunopathology . 2008,第3a4期

机译：持续感染口蹄疫病毒的牛的粘膜免疫反应增强。
2. Shifting to foot-and-mouth disease-free status without vaccination: Application of the PROMETHEE method to assist in the development of a foot-and-mouth national program in Uruguay [J] . Corbellini Luis Gustavo, Fernandez Federico, Vitale Edgardo, Preventive Veterinary Medicine . 2020,第1期

机译：在没有疫苗接种的情况下转移到口蹄疫的疾病状态：在乌拉圭协助采用普通方法的应用，协助在乌拉圭的脚踏性国家计划开发
3. Subcellular distribution of swine vesicular disease virus proteins and alterations induced in infected cells: a comparative study with foot-and-mouth disease virus and vesicular stomatitis virus. [J] . Martin-Acebes MA, Gonzalez-Magaldi M, Rosas MF, Virology . 2008,第2期

机译：猪水泡病病毒蛋白的亚细胞分布和感染细胞中诱导的改变：口蹄疫病毒和水疱性口炎病毒的比较研究。
4. Field safety study of a vaginal mucosal vaccination for porcine reproductive and respiratory syndrome virus (PRRSV) in sows [C] . Annual Meeting of the American Association of Swine Veterinarians . 2018

机译：猪繁殖和呼吸综合征病毒（PRRSV）阴道粘膜疫苗接种的现场安全性研究
5. Vaccination of chicks against infectious bursal disease virus. [D] . Al-Natour, Mohammad Qasem. 1996

机译：雏鸡接种传染性法氏囊病病毒。
6. Enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. III. Evaluation of antibodies after infection and vaccination. [O] . C. Hamblin, R. P. Kitching, A. I. Donaldson, 1987

机译：酶联免疫吸附测定（ELISA）用于检测针对口蹄疫病毒的抗体。三感染和疫苗接种后的抗体评估。
7. Enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. III. Evaluation of antibodies after infection and vaccination. [O] . Hamblin, C., Kitching, R. P., Donaldson, A. I., 1987

机译：酶联免疫吸附测定（ELISA），用于检测针对口蹄疫病毒的抗体。三，感染和疫苗接种后的抗体评估。

Porcine mucosal vaccination against foot-and-mouth disease virus.

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