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首页> 外文学位 >Characterizing high velocity angular vestibulo ocular reflex function in service members post blast exposure.
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Characterizing high velocity angular vestibulo ocular reflex function in service members post blast exposure.

机译：爆炸暴露后表征服务成员中高速角前庭眼反射功能。

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摘要

Purpose. Blasts are the most common mechanism of injury in modern warfare. Traumatic Brain Injury (TBI) and dizziness are common sequelae associated with blast exposure, however little is known about their underlying cause. Data suggest Service Members (SMs) with complaints of dizziness may have vestibular dysfunction. It has also been suggested that dizziness experienced during running may be related to pitch plane gaze instability. The purpose of this study was to prospectively assay the vestibular systems of blast-exposed SMs with TBI and assess their symptoms while running.;Methods. 24 SMs recovering from mild or moderate TBI sustained in Iraq or Afghanistan were prospectively assigned to one of two groups based on presence or absence of dizziness. Wireless monocular scleral search coil and rate sensor was used to characterize yaw and pitch plane angular vestibulo-ocular reflex (aVOR) gain. Visual analog scale (VAS) was used to monitor subject severity of vestibular symptoms during an exertional treadmill protocol. Each subject was assessed using standard vestibular function tests.;Results. The aVOR during yaw head impulses in the symptomatic group were lower for active impulses (Ga symptomatic = .794 +/- .15, Ga asymptomatic = .867 +/- .18) but not passive rotations (Ga symptomatic = .781 +/- .14, Ga asymptomatic = .745 +/- .18) (p= 0.0005). For pitch head rotations, aVOR gains were lower in the symptomatic group (active Ga = 0.915 +/- .24, passive Ga = 0.878 +/- .22) than the asymptomatic group (Ga = 1.03 +/- .27, passive pitch Ga = 0.97 +/- .23) (p= 0.004). VAS was worse for severity of vertigo, oscillopsia, motion intolerance, and dysequilibrium during and after treadmill testing relative to baseline (p 0.05).;Conclusion. Our findings suggest highly variable injury profiles in blast-exposed SMs including deficient as well as elevated aVOR responses. Our data demonstrate that some symptomatic SMs have diminished capability to generate compensatory eye movement responses during high velocity, actively generated head movements, which are typically greater than those during passive head rotations. This may suggest disruption of the efference copy to the brainstem vestibular nuclei.
机译：目的。爆炸是现代战争中最常见的伤害机制。创伤性脑损伤（TBI）和头晕是爆炸暴露的常见后遗症，但对其潜在原因知之甚少。数据表明，抱怨头晕的服务会员（SM）可能患有前庭功能障碍。还建议在跑步过程中出现的头晕可能与俯仰平面的注视不稳定性有关。这项研究的目的是前瞻性分析TBI与爆炸暴露的SM的前庭系统，并在运行时评估其症状。根据头晕的存在与否，将24例从在伊拉克或阿富汗持续的轻度或中度TBI康复中恢复的SM分为两组之一。无线单眼巩膜搜索线圈和速率传感器用于表征偏航角和俯仰平面角前庭眼反射（aVOR）增益。视觉模拟量表（VAS）用于监测运动型跑步机方案中受试者前庭症状的严重程度。使用标准的前庭功能测试对每个受试者进行评估。对于主动脉冲（Ga有症状= .794 +/- .15，Ga无症状= .867 +/- .18），症状组偏航头脉冲期间的aVOR较低，但被动旋转（Ga有症状= .781 + /）没有-.14，Ga无症状= .745 +/- .18）（p = 0.0005）。对于变桨头旋转，有症状组（有源Ga = 0.915 +/- .24，无源Ga = 0.878 +/- .22）的aVOR增益低于无症状组（Ga = 1.03 +/- .27，无源音调） Ga = 0.97 +/- .23）（p = 0.004）。在跑步机测试期间和之后，相对于基线，VAS的眩晕，震颤，运动不耐症和运动不平衡的严重程度较差（p <0.05）。我们的研究结果表明，爆炸暴露的SM的伤害变化很大，包括缺乏和升高的AVOR反应。我们的数据表明，某些症状性SM在高速，主动产生的头部运动（通常大于被动头部旋转过程中的运动）期间，产生代偿眼动响应的能力降低。这可能表明干扰复制到脑干前庭核。

著录项

  • 作者

    Scherer, Matthew R.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Biology Neuroscience.;Health Sciences Rehabilitation and Therapy.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 226 p.
  • 总页数 226
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

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