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The exercise stress response: The role of the sex hormones and temperature.

机译：运动压力反应：性激素和体温的作用。

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摘要

Sex is a potent modifier of the cardiovascular system as males and females differ in several aspects of the biology and physiology of the heart. Pre-menopausal women possess a distinct advantage over men in the incidence of cardiovascular disease, however males, as opposed to females, are provided with some benefit once a negative cardiac event has occurred. The reasons for these differences are not completely understood and are likely due to many factors, but an important conclusion from these observations is that sex hormones appear to be important regulators of myocardial health. Of particular note, the sex hormones appear to influence the induction of the cardioprotective heat shock protein, Hsp70, by exercise. Male rats exhibit a robust increase in cardiac Hsp70 after a single bout of treadmill running while females tend not to show this effect unless subjected to multiple bouts or chronic endurance exercise training. While the inhibition in females has been linked to estrogen, the role of testosterone in this response has not been determined. Current studies were undertaken in the current body of work that examined the role of endogenous and exogenous testosterone treatment on the endurance exercise stress response in intact and testosterone deficient rats as well as intact female animals. Moreover, the roles of estrus cycle stage, the ovarian hormones and exercise stress markers/events including temperature in exercising female rats were determined on both the acute (i.e. mRNA by reverse transcription real time polymerase chain reaction) and longer period (i.e. protein by Western blotting) expression of the Hsp70 gene. Significant findings include the observation that testosterone is required by the male rat to garner the potentially cardio-protective increase in cardiac Hsp70 and that estrus cycle stage and ovarian hormones are correlated with the response in females. Moreover, exercise temperature is the best correlate with Hsp70 gene expression suggesting that exercise intensity plays an important role in the exercise stress response in both sexes. A better understanding of how sex hormones modify the exercise stress response has important implications in the prescription of exercise for males and females both young and old.; Keywords. Sex, gender, hormones, heart, exercise, physical activity, health, estrogen, testosterone, stress, heat shock proteins.
机译：性别是心血管系统的有效调节剂，因为男性和女性在心脏生物学和生理学的几个方面都不同。绝经前女性在心血管疾病的发病率方面比男性具有明显优势，但是，一旦发生负性心脏事件，男性（而不是女性）将获得一些好处。这些差异的原因尚不完全清楚，可能是由许多因素引起的，但是从这些观察中得出的重要结论是，性激素似乎是心肌健康的重要调节剂。特别值得注意的是，性激素似乎通过运动影响心脏保护性热休克蛋白Hsp70的诱导。雄性大鼠在单轮跑步机上跑步后，心脏Hsp70会显着增加，而雌性则不会表现出这种效果，除非进行多次运动或进行长期耐力运动训练。尽管雌激素的抑制作用与雌激素有关，但尚未确定睾丸激素在该反应中的作用。当前的工作正在进行中，研究了内源性和外源性睾丸激素治疗对完整和睾丸激素缺乏症大鼠以及完整雌性动物的耐力运动应激反应的作用。此外，发情周期阶段，卵巢激素和运动应激标记/事件（包括温度）在雌性大鼠运动中的作用在急性期（即通过逆转录实时聚合酶链反应的mRNA）和更长的时期（即Western的蛋白质）都得到了确定。 Hsp70基因的表达）。重要发现包括以下观察结果：雄性大鼠需要睾丸激素才能获得心脏Hsp70潜在的心脏保护性增加，并且发情周期阶段和卵巢激素与雌性反应相关。此外，运动温度是与Hsp70基因表达的最佳相关性，表明运动强度在男女双方的运动应激反应中都起着重要作用。对性激素如何改变运动压力反应的更好理解，对男女老少的运动处方都有重要的意义。关键字。性别，性别，激素，心脏，运动，体育锻炼，健康，雌激素，睾丸激素，压力，热休克蛋白。

著录项

  • 作者

    Milne, Kevin J.;

  • 作者单位

    The University of Western Ontario (Canada).;

  • 授予单位 The University of Western Ontario (Canada).;
  • 学科 Biology Animal Physiology.; Health Sciences Recreation.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;预防医学、卫生学;
  • 关键词

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