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首页> 外文学位 >Neurochemical interactions in an animal model of parkinsonian tremor: Behavior, pharmacology, and the role of transcription factors as markers of striatal cell activity.
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Neurochemical interactions in an animal model of parkinsonian tremor: Behavior, pharmacology, and the role of transcription factors as markers of striatal cell activity.

机译：帕金森氏震颤动物模型中的神经化学相互作用：行为，药理学和转录因子作为纹状体细胞活性标记的作用。

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摘要

A series of 21 experiments were performed to study the effects of typical and atypical antipsychotics in terms of their ability to induce tremulous jaw movements (TJMs), to characterize the pharmacological interactions that regulate TJMs, and to identify cell signaling molecules that could be used as markers of the neural processes related to the generation of TJMs. The studies in Chapter 2 investigated the behavioral effects of the typical antipsychotic pimozide. Chapter 3 investigated immediate early gene (IEG) expression after sub-chronic administration of pimozide and its relation to behavior. The experiments in Chapter 4 investigated the behavioral effects of the atypical antipsychotic quetiapine, while Chapter 5 focused on IEG expression after sub-chronic administration of quetiapine and its relation to behavior. Chapter 6 consisted of behavioral pharmacology studies that focused upon the ability of drugs from various classes (i.e., 5HT2A/C antagonists, dopamine D1 receptor antagonists, muscarinic antagonists and adenosine A2A antagonists) to attenuate drug-induced TJM activity in order to characterize the effects of drugs that have putative antiparkinsonian characteristics. The last group of experiments (Chapter 7) investigated the reversal of dopamine antagonist-induced IEG expression in the striatum with adenosine A2A and acetylcholinergic muscarinic M4 antagonism. Taken together, the present studies have provided further evidence for the action of pimozide exerting its "typical" antipsychotic effects via blockade of DA receptors in the basal ganglia and that the TJM model can be useful for assessing the effects of antiparkinsonian drugs from a variety of different classes after sub-chronic administration of pimozide. In summary, the research presented may help to characterize the specific role that striatal activity plays in the neuronal networks of the basal ganglia, and how intracellular responses ultimately can be related to specific aspects of motor function.
机译：进行了21项实验，研究了典型和非典型抗精神病药诱导下颌颤动（TJM）的能力，表征调节TJM的药理相互作用以及鉴定可被用作抗精神病药的细胞信号分子的作用。与TJM产生有关的神经过程标记。第2章中的研究调查了典型抗精神病药物pimozide的行为效应。第3章研究了亚吡莫嗪治疗后的即刻早期基因（IEG）表达及其与行为的关系。第4章中的实验研究了非典型抗精神病药物喹硫平的行为效应，而第5章重点研究了喹硫平亚慢性给药后IEG的表达及其与行为的关系。第6章包含行为药理学研究，这些研究集中于各种药物（即5HT2A / C拮抗剂，多巴胺D1受体拮抗剂，毒蕈碱拮抗剂和腺苷A2A拮抗剂）减弱药物诱导的TJM活性以表征其作用的能力。具有推定的抗帕金森病特征的药物。最后一组实验（第7章）研究了腺苷A2A和乙酰胆碱能毒蕈碱M4拮抗作用逆转多巴胺拮抗剂诱导的纹状体中IEG表达。综上所述，本研究提供了进一步的证据，证明匹莫西特通过阻断基底神经节中的DA受体发挥其“典型”抗精神病作用，并且TJM模型可用于评估来自多种不同药物的抗帕金森病药物的作用。亚慢性给予匹莫齐后可分为不同的类别。总之，提出的研究可能有助于表征纹状体活动在基底神经节神经元网络中发挥的特定作用，以及细胞内应答最终如何与运动功能的特定方面相关。

著录项

  • 作者

    Betz, Adrienne J.;

  • 作者单位

    University of Connecticut.;

  • 授予单位 University of Connecticut.;
  • 学科 Biology Neuroscience.; Psychology Psychobiology.; Psychology Behavioral.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 188 p.
  • 总页数 188
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;心理学;心理学;
  • 关键词

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