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Complexity in non-isothermal polymerization of PMMA based bone cement: Thermal, chemical, and mechanical effects on polymerization fronts

机译：PMMA基骨水泥非等温聚合的复杂性：聚合前沿的热，化学和机械效应

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摘要

Poly (methyl methacrylate) (PMMA) bone cements have been successfully used as a space-filler between the bony structure and the metal prosthesis through the last half century, however, the material does have several drawbacks. The main one is that aseptic loosening is still the major reason for revision in clinical life. The etiology of cement loosening remains unclear. This is, in part, the result of limited understanding of what factors affect long-term performance of cement in vivo.;In this study, it is hypothesized that the structural and mechanical properties across the cement mantle are heterogeneously distributed due to the process of MMA polymerization, under in vivo non-isothermal conditions (i.e., bone (37°C) → prosthesis (RT)). The goals of this study are to investigate the effects of complexities of the chemical, thermal, and diffusional-dependent polymerization interactions on the structural and mechanical properties and to develop empirical test techniques that allow one to monitor and predict the complexities of the in vivo non-isothermal polymerization of the PMMA bone cement.;A new empirical polymerization model, based on a new overall rate constant analysis technique, was developed using isothermal differential scanning calorimetry (Iso-DSC) to precisely predict the local polymerization behavior. This complex polymerization behavior, under non-isothermal conditions, formed the spatio-temporal polymerization front that progressed from the warmest side to the coolest side. During the polymerization front progression, higher porosity at the coolest side and higher residual stresses at the warmest side were developed depending on the thermal gradient. The heterogeneous micromechanical property distribution across the cement mantle correlates with the structural property distributions. Under the in vivo non-isothermal condition, the structural and mechanical heterogeneities in the 20-35°C case led to the higher crack formations under the compression test.;Polymerization fronts are a possible reason why aseptic failure of the PMMA bone cements still remains at a high rate. The non-isothermal condition leads to the asymmetric heterogeneities in the structural and mechanical properties across the cement mantle.
机译：在过去的半个世纪中，聚甲基丙烯酸甲酯（PMMA）骨水泥已成功地用作骨结构与金属假体之间的空间填充物，但是，该材料确实存在一些缺点。主要的原因是无菌性松动仍然是临床生活中改变的主要原因。水泥松动的病因仍不清楚。这部分是由于对哪些因素会影响水泥在体内的长期性能的了解有限所致。在本研究中，假设整个水泥地幔的结构和力学性质由于其过程而异质分布。在体内非等温条件下（即骨骼（37°C）→假体（RT））进行MMA聚合。这项研究的目的是研究化学，热和扩散相关的聚合反应的复杂性对结构和机械性能的影响，并开发经验性的测试技术，以监测和预测体内非化学反应的复杂性。 -等温聚合的PMMA骨水泥。基于新的整体速率常数分析技术，使用等温差示扫描量热法（Iso-DSC）开发了一种新的经验聚合模型，以精确预测局部聚合行为。在非等温条件下，这种复杂的聚合行为形成了时空聚合前沿，该前沿从最暖的一侧发展到最冷的一侧。在聚合前沿进行期间，取决于热梯度，在最冷侧产生较高的孔隙率，在最热侧产生较高的残余应力。跨水泥幔的非均质微机械性能分布与结构性能分布相关。在体内非等温条件下，在20-35°C的情况下结构和机械异质性在压缩试验下导致较高的裂纹形成。聚合前沿是仍可能导致PMMA骨水泥无菌失效的可能原因很高的速度。非等温条件导致整个水泥地幔在结构和力学性能上的不对称异质性。

著录项

  • 作者

    Shim, Jae-Bum.;

  • 作者单位

    Syracuse University.;

  • 授予单位 Syracuse University.;
  • 学科 Biomedical engineering.;Polymer chemistry.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 178 p.
  • 总页数 178
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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