• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Biomimetic synthesis of poly(propylene-fumarate)-calcium phosphate composites for tissue engineering.
【24h】

Biomimetic synthesis of poly(propylene-fumarate)-calcium phosphate composites for tissue engineering.

机译：用于组织工程的聚（富马酸丙烯）-磷酸钙复合材料的仿生合成。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel in-situ co-precipitation process for the synthesis of poly(propylene-fumarate)-calcium phosphate composites was developed. In this process the calcium phosphate phase nucleates and grows in the presence of poly(propylene-fumarate) (PPF), in a novel two-solvent system including tetrahydrofuran (THF) and water. It was found that the presence of the organic solvent (THF) does not affect the phase evolution of the calcium phosphate. Both in the presence and absence of THF crystalline dicalcium phosphate dihydrate (DCPD, brushite) and poorly crystalline hydroxyapatite (HAp) form, and transform to crystalline HAp after 24 hours of synthesis time. Contrary to the organic solvent, PPF has a significant influence on the calcium phosphate phase that forms in its presence. It is found that PPF provides a template for the formation of the calcium phosphate phase through a coordination bond between the calcium ion and the carbonyl group of the polymer. As a result of this templating, hydroxyapatite can form in a significantly shorter period of time (∼1 hr) compared to the system where PPF is not present (24 hrs). The nature of the calcium phosphate phase that forms in the presence of PPF depends on the molecular weight and concentration of PPF. High concentration of PPF in the composite (e.g. 80%) stabilizes an amorphous calcium phosphate (ACP) phase and hinders its transformation to crystalline apatite, while low concentration of PPF (e.g. 5%) promotes the formation of crystalline apatite. Higher molecular weight PPF (Mw = 4500) is found to be more efficient in stabilizing the amorphous phase compared to lower molecular weight PPF (Mw = 1800). While high molecular weight PPF stabilizes ACP, low molecular weight PPF promotes its conversion to crystalline apatite. TEM observations revealed that flake-like hydroxyapatite crystals form in the absence of PPF while spherical ACP particles form in a composite containing 80% PPF. The ACP nano-particles (50-100 nm in diameter) are homogeneously distributed within the PPF matrix. The PPF-calcium phosphate composite can crosslink into a 3D structure by UV irradiation.
机译：开发了一种新颖的原位共沉淀法合成聚（富马酸丙烯酯）-磷酸钙复合材料。在此过程中，磷酸钙相在包括四氢呋喃（THF）和水在内的新型两溶剂系统中，在聚富马酸丙烯酯（PPF）的存在下成核并生长。发现有机溶剂（THF）的存在不影响磷酸钙的相演变。在存在和不存在THF结晶磷酸二钙二水合物（DCPD，透钙磷石）和结晶度较差的羟基磷灰石（HAp）的情况下，在合成24小时后均转化为结晶HAp。与有机溶剂相反，PPF对在其存在下形成的磷酸钙相具有重大影响。发现PPF通过钙离子和聚合物的羰基之间的配位键提供了形成磷酸钙相的模板。这种模板化的结果是，与不存在PPF的系统（24小时）相比，羟基磷灰石可以在更短的时间内（约1小时）形成。在PPF存在下形成的磷酸钙相的性质取决于PPF的分子量和浓度。复合物中PPF的高浓度（例如80％）稳定了无定形磷酸钙（ACP）相并阻碍了其转变为结晶磷灰石，而PPF的低浓度（例如5％）则促进了结晶磷灰石的形成。与较低分子量的PPF（Mw = 1800）相比，发现较高的分子量PPF（Mw = 4500）在稳定非晶相方面更有效。高分子量PPF使ACP稳定，而低分子量PPF促进其转化为结晶磷灰石。 TEM观察表明，在不存在PPF的情况下会形成片状羟基磷灰石晶体，而球形ACP颗粒则在包含80％PPF的复合材料中形成。 ACP纳米颗粒（直径为50-100 nm）均匀分布在PPF基质中。 PPF-磷酸钙复合材料可以通过紫外线照射交联成3D结构。

著录项

  • 作者

    Hakimi Mehr, Dorna.;

  • 作者单位

    The University of British Columbia (Canada).;

  • 授予单位 The University of British Columbia (Canada).;
  • 学科 Engineering Materials Science.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 129 p.
  • 总页数 129
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号