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首页> 外文学位 >Effects of psychological stress and cytokine genes on humoral immune response to tetanus toxoid adsorbed in family caregivers of Alzheimer's disease patients.
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Effects of psychological stress and cytokine genes on humoral immune response to tetanus toxoid adsorbed in family caregivers of Alzheimer's disease patients.

机译：心理应激和细胞因子基因对阿尔茨海默氏病患者家属照顾者对破伤风类毒素吸附的体液免疫反应的影响。

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摘要

Vaccine-induced antibody response is a complex process determined by both genetic and non-genetic factors. A family-based cohort study was conducted to assess the effects of chronic psychological stress and cytokines genes on the antibody response to tetanus vaccine and to estimate the heritability of antibody response in 119 spouses and offspring of community-dwelling patients with Alzheimer's disease (AD). Psychological stress was measured by the Perceived Stress Scale (PSS) and the Center for Epidemiologic Research-Depression (CES-D) scale. Blood samples were collected at baseline and one month after tetanus vaccination. Ten single nucleotide polymorphism (SNP) markers on IL-1beta, IL-2, IL-12, TNF-alpha, IL-10, and IL-4 were genotyped. The anti-tetanus (TT) IgG was tested using ELISA. The antibody response was analyzed as the difference between the log10 (post-anti-TT IgG) and log10 (pre-anti-TT IgG). The psychological stress variables were analyzed using their original scales and factor scores obtained by principal component analyses. The results using mixed models showed that every point increase in the CES-D score was associated with 10.75% less antibody fold increase (p=0.0023), every point increase in the PSS score was associated with 4.8% less antibody fold increase (p=0.075), the effect of the factor score formed by factor loadings from CES-D and PSS scores was even larger, with every point increase associated with 31% less antibody fold increase (p=0.019). The TNF-alpha -238 A>G GG genotype was associated with 215.0% greater antibody fold increase compared to the AA+AG genotypes (p=0.0028). Age and self-reported arthritis were also positively associated with the antibody response. The crude and adjusted heritability estimates in the parent-offspring pairs for the post-anti-TT IgG were 0.40 (95% CI: -0.05, 0.86) and 0.28 (95% CI: -0.18, 0.76), respectively. The study provided additional evidence on the detrimental effects of psychological stress on the antibody response to the tetanus vaccine. Furthermore, the results suggested that the TNF-alpha -238 A/G locus may influence the antibody response through its regulation on transcription and production of TNF-alpha.
机译：疫苗诱导的抗体反应是一个复杂的过程，由遗传和非遗传因素共同决定。进行了一项基于家庭的队列研究，以评估慢性心理压力和细胞因子基因对破伤风疫苗的抗体反应的影响，并评估在119名患有阿尔茨海默氏病（AD）的社区患者的配偶和后代中抗体反应的遗传力。心理压力是通过感知压力量表（PSS）和流行病学研究抑郁症中心（CES-D）量表测量的。在基线和破伤风疫苗接种后一个月收集血液样本。对IL-1beta，IL-2，IL-12，TNF-alpha，IL-10和IL-4上的十个单核苷酸多态性（SNP）标记进行了基因分型。使用ELISA检测抗破伤风（TT）IgG。分析抗体应答，作为log10（抗TT IgG后）和log10（抗TT IgG前）之间的差异。心理压力变量使用其原始量表和通过主成分分析获得的因子得分进行分析。使用混合模型的结果表明，CES-D分数的每点增加与抗体倍数增加减少10.75％相关（p = 0.0023），PSS分数的每点增加与抗体倍数增加减少4.8％相关（p = 0.075），由CES-D和PSS评分中的因子加载所形成的因子评分的影响甚至更大，每增加一个点，抗体倍数增加就减少31％（p = 0.019）。与AA + AG基因型相比，TNF-α-238 A> G GG基因型与抗体倍数增加215.0％相关（p = 0.0028）。年龄和自我报告的关节炎也与抗体反应呈正相关。抗TT后IgG的亲本-子代对中的粗略和调整后的遗传力估计分别为0.40（95％CI：-0.05，0.86）和0.28（95％CI：-0.18，0.76）。该研究为心理压力对破伤风疫苗抗体反应的有害影响提供了补充证据。此外，结果表明，TNF-α-238 A / G基因座可能通过调节其对TNF-α的转录和产生而影响抗体反应。

著录项

  • 作者

    Li, Jian.;

  • 作者单位

    The University of Alabama at Birmingham.;

  • 授予单位 The University of Alabama at Birmingham.;
  • 学科 Biology Molecular.; Psychology Psychobiology.; Biology Genetics.; Health Sciences Nursing.; Health Sciences Immunology.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 111 p.
  • 总页数 111
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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