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首页> 外文学位 >Frontal lobe morphology in macrocephalic and normocephalic autistic subjects: A quantitative magnetic resonance imaging study.
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Frontal lobe morphology in macrocephalic and normocephalic autistic subjects: A quantitative magnetic resonance imaging study.

机译：大头和正头自闭症患者的额叶形态：定量磁共振成像研究。

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Objective. The prevalence of macrocephaly (head circumference >97th percentile) is approximately seven fold greater in autistic individuals compared to controls. In this study, frontal lobe morphology was examined in macrocephalic autistic, normocephalic autistic, typically developing, and benign macrocephalic subjects. The following three questions were addressed. (1) Do macrocephalic autistic subjects, normocephalic autistic, benign macrocephalic, and typically developing subjects exhibit differences in frontal lobe volume after controlling for age, intelligence, and head size? (2) Do macrocephalic and normocephalic subjects show similar patterns of frontal lobe development? (3) Do autistic subjects, irrespective of head size classification, show distinct patterns of frontal lobe development compared to controls? Method. Male autistic subjects ages 7-31 years were diagnosed using the Autism Diagnostic Interview-Revised and the Autism Diagnostic Observation Schedule-Generic. Multispectral brain image analysis was carried out for frontal gray and white matter volumes. Results. There were no volumetric differences between the four groups on measures of frontal gray matter, frontal white matter, or total frontal volume after controlling for age, intelligence, and head size. Within the autistic and control groups, the relationships between age and gray matter, white matter, and total frontal volumes were similar for macrocephalic and normocephalic subjects. When macrocephalic and normocephalic subjects were combined into autistic and control groups, age-frontal morphology regression analyses showed a significant decrease in frontal gray matter volume with increasing age in the autistic but not the control group. There was no association between age and white matter volume for either the autistic or control groups. Conclusions. The results of the current study suggest that macrocephalic and normocephalic subjects may be able to be combined in future studies. It is critical to examine frontal lobe morphology as a function of development, as study designs that control age may obscure important differences between autistic and control groups. Further research is needed to elucidate the mechanism(s) underlying the finding of decreased gray matter volume found with increasing age in autism.
机译：目的。与对照组相比，自闭症患者的大头畸形（头围> 97％）高大约7倍。在这项研究中，在大头自闭症，常头自闭症（通常是发育中的）和良性大头颅受试者中检查了额叶形态。解决了以下三个问题。 （1）在控制了年龄，智力和头部大小之后，大头自闭症，正头自闭，良性大头畸形和典型发育中的受试者的额叶体积是否存在差异？ （2）大头颅和正常头颅受试者是否表现出相似的额叶发育模式？ （3）与对照组相比，自闭症患者，无论头部大小如何，是否表现出明显的额叶发育模式？方法。使用修订的《自闭症诊断访谈》和《自闭症诊断观察时间表》对7-31岁的男性自闭症患者进行诊断。对额灰和白质体积进行了多光谱脑图像分析。结果。在控制年龄，智力和头部大小后，四组在额叶灰质，额叶白质或额叶总体积的测量上没有体积差异。在自闭症和对照组中，大头和正头对象的年龄与灰质，白质和总额叶体积之间的关系相似。当将大头颅和正常头颅的受试者合并为自闭症和对照组时，年龄-额叶形态回归分析显示自闭症患者的额叶灰质体积随年龄的增加而显着下降，而对照组则没有。自闭症或对照组的年龄与白质量之间没有关联。结论。当前研究的结果表明，大头和正头对象可能在将来的研究中可以合并。检查额叶形态与发育的关系至关重要，因为控制年龄的研究设计可能掩盖了自闭症患者和对照组之间的重要差异。需要进一步的研究来阐明发现自闭症年龄增加时灰质体积减少的潜在机制。

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