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首页> 外文学位 >Phase-Amplitude Cross-Frequency Coupling in the Globus Pallidus Internus and Motor Cortex of Patients with Parkinson's Disease.
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Phase-Amplitude Cross-Frequency Coupling in the Globus Pallidus Internus and Motor Cortex of Patients with Parkinson's Disease.

机译：帕金森氏病患者的苍白球间质和运动皮层中的相幅跨频耦合。

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摘要

Different models of the cortico-basal ganglia thalamocortical circuit are currently in existence, pointing to an incomplete understanding of those nuclei. Decades long research efforts have established the presence of oscillations in the basal ganglia and their link to functional and pathological states. More recently, hierarchical relations between those oscillations have also been shown to be functionally relevant. Phase-amplitude cross frequency coupling (PACFC), in particular, has been shown to exist within and between the human subthalamic nucleus (STN) and motor areas of the cortex. In our study we report high levels of PACFC in the human GPi of patients with Parkinson's disease (PD) and show its high correlation to local spectral power as well as coherence across GPi and motor cortex. Cross-site bidirectional PACFC was also shown to exist between the two sites in a small number of subjects. Contralateral finger movement seemed to significantly decrease coupling only in some subjects, possibly manifesting a deficiency in the diseased BG. The angle of modulation was about 28% the period of the slow oscillation and one subject had unusually high coupling (z-score = 148). The coupling was the strongest for the beta-gamma band pair, while there were also beta - (200-300 Hz) and theta - beta coupling to a lesser extent in a subset of subjects. The findings mark advances in our understanding of a nucleus that has received little attention compared to the STN, as well as its relation to the motor cortex.
机译：目前存在皮质-基底神经节丘脑皮层回路的不同模型，这表明对这些核的理解不完整。数十年的长期研究工作已经确定了基底神经节中振荡的存在及其与功能和病理状态的联系。最近，这些振荡之间的分层关系也已经显示出在功能上是相关的。业已证明，尤其是相幅交叉频率耦合（PACFC）存在于人丘脑底核（STN）与皮质运动区之间和之间。在我们的研究中，我们报告了帕金森氏病（PD）患者人GPi中PACFC的高水平，并表明其与局部光谱功率以及GPi和运动皮层的相干性高度相关。跨站点双向PACFC还显示在少数对象中的两个站点之间。仅在某些对象中，对侧手指的移动似乎会显着降低耦合，这可能表明患病的BG缺乏。调制角约为缓慢振荡周期的28％，一名受试者的耦合异常高（z分数= 148）。对于β-γ波段对，耦合最强，而在一部分受试者中，β-（200-300 Hz）和θ-β耦合程度较小。这些发现标志着我们对与STN相比很少受到关注的核及其与运动皮层的关系的了解的进一步发展。

著录项

  • 作者

    Tsiokos, Christos.;

  • 作者单位

    University of California, Los Angeles.;

  • 授予单位 University of California, Los Angeles.;
  • 学科 Engineering Biomedical.;Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 141 p.
  • 总页数 141
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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