• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Development and Application of High-Throughput Sample Preparation Methods for Solid Matrices
【24h】

Development and Application of High-Throughput Sample Preparation Methods for Solid Matrices

机译：固体基质高通量样品制备方法的开发与应用

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This research presents the development and application of high-throughput sample preparation methods for the analysis of organic and inorganic contaminants from solid samples. The approach presented evaluates conventional methods to identify potential areas of improvement. In this sense, conventional methods serve as a framework for the development of high-throughput sample preparation methods. In general, improvements include expansion of target analyte list thereby increase the environmental applicability, reduction of sample preparation steps, and as a result, reduction of sample preparation time.;The analytical bottleneck is often associated with sample preparation, especially in the analysis of organic contaminants from environmental samples. Many environmental analytical chemistry methods can be broken down into one or more sample preparation steps followed by one or more chemical analysis steps. Improvement of historical methods has focused on the development of advance instrumentation (i.e. focusing on the chemical analysis). However, recent efforts have focused on the overall reduction of time and/or steps associated with sample preparation. For example, post-extraction cleanup adsorbents can be incorporated into the pressurized liquid extraction step to perform a selective pressurized liquid extraction (SPLE). SPLE methods significantly reduced sample preparation time, solvent requirements, and waste production.;Specific examples presented in this dissertation include: 1) the development and application of SPLE methods for the analysis of organic contaminants from sediments and biological tissues; 2) the development and application of a simplified acid digestion method for the analysis of mercury and selenium in rare samples of Pacific walrus (Odobenus rosmarus divergens) muscle (L. dorsi). These examples illustrate the approach for the development of high-throughput sample preparation methods that have successfully combined techniques into a single method, and/or eliminated post-extraction cleanup steps. The availability of these methods increases laboratory's capacity and preparedness to analyze rapidly large volumes of samples. These methods could find use in routine analysis and monitoring studies of environmental samples, food and pharmaceutical industries, agriculture, toxicology studies, and forensic sciences among others. Lastly, this dissertation discusses a few opportunities that lay ahead for improvement and development in sample preparation.
机译：这项研究提出了高通量样品制备方法在固体样品中有机和无机污染物分析中的开发和应用。提出的方法评估了常规方法，以确定潜在的改进领域。从这个意义上讲，常规方法可作为开发高通量样品制备方法的框架。通常，改进包括扩展目标分析物列表，从而提高环境适用性，减少样品制备步骤，并因此减少样品制备时间。分析瓶颈通常与样品制备相关，尤其是在有机物分析中来自环境样品的污染物。许多环境分析化学方法可以分为一个或多个样品制备步骤，然后是一个或多个化学分析步骤。历史方法的改进集中在高级仪器的开发上（即集中在化学分析上）。但是，最近的努力集中在总体上减少与样品制备有关的时间和/或步骤。例如，可以将萃取后净化吸附剂掺入加压液体萃取步骤中以进行选择性加压液体萃取（SPLE）。 SPLE方法显着减少了样品制备时间，溶剂需求量和废物的产生。本论文的具体实例包括：1）SPLE方法的开发和应用，用于分析沉积物和生物组织中的有机污染物。 2）简化的酸消解方法的开发和应用，用于分析太平洋海象（Odobenus rosmarus divergens）肌肉（L. dorsi）的稀有样品中的汞和硒。这些示例说明了开发高通量样品制备方法的方法，该方法已将技术成功地组合为一种方法，并且/或者消除了提取后的纯化步骤。这些方法的可用性提高了实验室分析大量样品的能力和准备能力。这些方法可用于环境样品，食品和制药业，农业，毒理学研究和法医学等的常规分析和监测研究。最后，本文讨论了一些改进和发展样品制备的机会。

著录项

  • 作者

    Aguilar, Lissette.;

  • 作者单位

    Baylor University.;

  • 授予单位 Baylor University.;
  • 学科 Environmental science.;Analytical chemistry.;Toxicology.;Food science.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 94 p.
  • 总页数 94
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号