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首页> 外文学位 >The effect of maternal antioxidant nutrient supplementation and age on chick post-hatch innate immune function.
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The effect of maternal antioxidant nutrient supplementation and age on chick post-hatch innate immune function.

机译：母体抗氧化剂营养补充剂和年龄对孵化后雏鸡先天免疫功能的影响。

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摘要

The chick's innate immune system may affect post-hatch liveability and performance, but is immature at hatch. The development of the immune system begins in ovo and may be affected by hen age and nutrition. Antioxidants are molecules capable of preventing and correcting oxidative damage and may play an important role in the innate immune response because reactive oxygen species are produced as a bactericidal mechanism. Supplementing hens with antioxidant ingredients may have a priming effect on the chick's innate immune development and increase the response post-hatch. The objective of this thesis was to investigate how hen age and nutrition affected chick post-hatch innate immunity.;Hens were supplemented with one of the antioxidant ingredients, canthaxanthin, synthetic or natural vitamin E or L-carnitine. At three hen ages: 31-33, 45-47, and 57-59 wks, fertile eggs were incubated and hatched. Whole blood was collected for the determination of innate immune function indices which included Escherichia coli bactericidal capacity (EBC), phagocytosis, oxidative burst and plasma total antioxidant capacity.;The maternal supplementation of each of these three ingredients demonstrated their immuno-modulatory potential in post-hatch chicks. Supplementing with 6 ppm canthaxanthin or natural vitamin E increased chick EBC which was a general measure of innate immune function; while L-carnitine supplementation increased chick oxidative burst. Supplementation of all three ingredients resulted in a three way interaction between hen treatment and age and chick age with respect to chick plasma total antioxidant capacity. The most consistent observation was that chick EBC decreased as hens aged leading to a study investigating the effects of maternal age and incubator temperature on chick innate immune function. Eggs from 26 to 34, 35 to 44 and 45 to 54 wk old hens were incubated at one of four incubator temperatures, 36.0, 36.5, 37.0, or 37.5°C. It was observed that chicks from 26 to 34 wk old hens had greater innate immune responses and that incubating eggs at 36.5°C resulted in the greatest innate immune response. This research supports published data that chick immune function is affected by incubation conditions and strongly suggests that it is greater in chicks from young hens.
机译：雏鸡的先天免疫系统可能会影响孵化后的生存能力和性能，但孵化时未成熟。免疫系统的发展始于卵，可能会受到母鸡年龄和营养的影响。抗氧化剂是能够预防和纠正氧化损伤的分子，并且在先天性免疫应答中可能起重要作用，因为活性氧是作为一种杀菌机制产生的。用抗氧化剂成分补充母鸡可能对雏鸡的先天免疫发育具有引发作用，并增加孵化后的反应。本文的目的是研究母鸡的年龄和营养状况如何影响雏鸡孵化后的先天免疫力。母鸡补充抗氧化剂成分角黄素，合成或天然维生素E或L-肉碱。在三个母鸡年龄：31-33、45-47和57-59周时，将可育卵孵化并孵化。收集全血以确定先天免疫功能指标，包括大肠杆菌的杀菌能力（EBC），吞噬作用，氧化爆发和血浆总抗氧化能力。母体补充这三种成分中的每一种都证明了其在免疫后的免疫调节潜力。孵化的小鸡。补充6 ppm的角黄素或天然维生素E可增加雏鸡EBC，这是先天免疫功能的一般指标；补充左旋肉碱可增加雏鸡的氧化爆发力。相对于雏鸡血浆总抗氧化能力，所有三种成分的补充导致母鸡处理与年龄和雏鸡年龄之间的三向相互作用。最一致的观察结果是，随着母鸡年龄的增长，雏鸡EBC下降，从而导致一项研究调查母体年龄和孵化温度对雏鸡先天免疫功能的影响。将26至34、35至44和45至54周龄的母鸡的鸡蛋在四个孵化器温度36.0、36.5、37.0或37.5°C之一进行孵化。据观察，年龄在26至34周龄的母鸡的先天免疫反应更大，在36.5°C的温度下孵化卵会产生最大的先天免疫反应。这项研究支持已发表的数据，表明雏鸡的免疫功能受孵化条件的影响，并强烈表明，在幼小母鸡中，雏鸡的免疫功能更高。

著录项

  • 作者

    Johnson, Melissa Lynn.;

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Agriculture Animal Culture and Nutrition.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 209 p.
  • 总页数 209
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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