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首页> 外文学位 >Dielectric barrier discharge (DBD) surface plasma sterilization: An in-depth study of the factors contributing to and enhancing the sterilization process.
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Dielectric barrier discharge (DBD) surface plasma sterilization: An in-depth study of the factors contributing to and enhancing the sterilization process.

机译：介质阻挡放电（DBD）表面等离子体灭菌：深入研究有助于和增强灭菌过程的因素。

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摘要

Plasma sterilization is a method in which ionized gas is used to treat contaminated objects or surfaces. It can be divided into two regimes: volume and surface plasma sterilization. While a lot of research has been done in understanding the former, the latter is yet to be fully explored. The purpose of this study is to identify and understand the key contributors controlling the process of surface plasma sterilization under atmospheric conditions.;This is accomplished by a two-pronged approach of parametric studies and mechanistic studies. The plasma used for the purpose of this study is known as dielectric barrier discharge (DBD) plasma. Parametric studies help characterize the dependence of sterilization on DBD surface plasma generation parameters such as input power, operating pressure etc. In doing so, the energy flux introduced by plasma (J/cm2) has been identified as an intrinsic parameter for sterilization. A threshold plasma dose of approximately 285 J/cm2 is required for complete bacterial inactivation in the case of E. coli.;The mechanism of the sterilization process is studied using diagnostic information measured in terms of spectroscopic signature, ozone concentrations and surface temperatures of the dielectric surface during plasma generation. Results from these studies imply that ozone plays a major role in the process of surface plasma sterilization. Isolating the role of temperature during plasma generation leads to the hypothesis that ozone and heat may play a synergistic role in the process of surface plasma sterilization.;Additionally, the interaction of plasma with the microorganisms is visualized using both high resolution microscopy and fluorescence microscopy. In studying plasma interaction with biofilms, it is determined that cell types expressing a matrix-forming phenotype are more susceptible to plasma treatment as compared to cell types expressing a motile phenotype. This provides a valuable insight into the effect of plasma treatment on the cell biology.;This dissertation demonstrates DBD surface plasma as a very effective sterilization method and identifies key control parameters and mechanisms. The understanding of such a technology will allow access to many life-critical medical technologies including self-sterilizing operating tables and food counters, and even portable sterilization kits for triage situations.
机译：等离子体灭菌是一种使用电离气体处理受污染物体或表面的方法。它可以分为两种方案：体积灭菌和表面等离子体灭菌。尽管在了解前者方面已经进行了许多研究，但尚未充分探索后者。这项研究的目的是识别和理解在大气条件下控制表面等离子体灭菌过程的关键因素。这是通过两方面的参数研究和机理研究来实现的。用于本研究目的的等离子体称为介电势垒放电（DBD）等离子体。参数研究有助于表征灭菌对DBD表面等离子体生成参数（如输入功率，工作压力等）的依赖性。在此过程中，等离子体引入的能量通量（J / cm2）已被确定为灭菌的固有参数。对于大肠埃希氏菌，要使细菌完全灭活，需要约285 J / cm2的阈值血浆剂量;使用光谱学特征，臭氧浓度和表面温度测量的诊断信息研究灭菌过程的机理等离子体生成过程中的介电表面。这些研究的结果表明，臭氧在表面等离子体灭菌过程中起着重要作用。在等离子体产生过程中隔离温度的作用导致以下假设：臭氧和热量可能在表面等离子体灭菌过程中起协同作用。此外，使用高分辨率显微镜和荧光显微镜可以观察到等离子体与微生物的相互作用。在研究血浆与生物膜的相互作用时，确定表达基质形成表型的细胞类型与表达运动型表型的细胞类型相比更易受血浆处理。这为等离子体处理对细胞生物学的影响提供了有价值的见解。本文证明了DBD表面等离子体是一种非常有效的灭菌方法，并确定了关键的控制参数和机理。对这种技术的理解将使人们能够使用许多对生命至关重要的医疗技术，包括自消毒手术台和食品柜，甚至是用于分类情况的便携式消毒套件。

著录项

  • 作者

    Mastanaiah, Navya.;

  • 作者单位

    University of Florida.;

  • 授予单位 University of Florida.;
  • 学科 Mechanical engineering.;Aerospace engineering.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 179 p.
  • 总页数 179
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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