• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Factors influencing variations in vaginal flora: The association between douching, condom use, and bacterial vaginosis (BV) in the GIFT study.
【24h】

Factors influencing variations in vaginal flora: The association between douching, condom use, and bacterial vaginosis (BV) in the GIFT study.

机译：影响阴道菌群变化的因素：GIFT研究中，冲洗，使用避孕套和细菌性阴道病（BV）之间的关联。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bacterial vaginosis (BV) is one of the most prevalent diseases in women of reproductive age; however, the natural history of BV is poorly understood. We characterized variations in vaginal flora by assessing factors that influence the persistence of BV and BV-associated organisms. In addition, we evaluated the potential impact that prior infection may have on the relationship between douching and BV, and assessed whether condom use may protect against BV. A total of 1199 women enrolled in the Gyn. Infections Follow-through Study were utilized for this study. Women were followed for a median of 3 years, and vaginal microbiology samples were obtained for Gram-stain diagnosis of BV and culture of microflora at baseline and every 6 to 12 months thereafter. After adjusting for confounding factors, only black race (adjusted RR 1.47, 95% CI 1.09, 1.98) and a baseline Gram-stain of BV (adjusted RR 6.60, 95% CI 4.41, 9.87) increased the risk of persistent BV. Other factors, commonly associated with BV in cross-sectional analyses were not associated with persistent BV. In cross-sectional analyses, douching at least once per month was associated with BV among women who had a history of BV, but not among women without prior experience of BV. In prospective analyses, douching only increased the risk of acquisition for BV among women with intermediate flora at baseline (adj. HR 1.5, 95% CI 1.1-2.4), suggesting that douching may lead to BV among women with abnormal flora. Consistent condom use (10 out 10 sexual encounters) was associated with a decreased frequency of BV in case-crossover analyses (adjusted OR = 0.68, 95% CI = 0.49-0.94, p for trend = 0.047). Similar results were seen for carriage of M. hominis (adjusted OR = 0.61, 95% CI: 0.41-0.93) and anaerobic Gram-negative pigmented rods (OR = 0.65, 95% CI: 0.47-0.91). These results identify women at high risk for persistent infection, and among women with a history of BV douching should be avoided. This study also provided evidence that condoms are protective against BV. Given the high proportion of women with BV, the identification of protective factors is of significant public health importance for reducing the prevalence of BV.
机译：细菌性阴道病（BV）是育龄妇女中最流行的疾病之一；然而，人们对BV的自然历史知之甚少。我们通过评估影响BV和BV相关生物持续性的因素来表征阴道菌群的变化。此外，我们评估了先前感染可能对冲洗和BV之间关系的潜在影响，并评估了使用安全套是否可以预防BV。妇科医生中共有1199名妇女。感染随访研究被用于该研究。对女性进行了3年的中位随访，并在基线时以及之后每6到12个月获取阴道微生物学样本，用于革兰氏染色诊断BV和进行菌群培养。调整混杂因素后，只有黑人（调整后的RR 1.47、95％CI 1.09、1.98）和基线革兰氏染色（调整后的RR 6.60、95％CI 4.41、9.87）增加了持续性BV的风险。在横截面分析中通常与BV相关的其他因素与持久性BV不相关。在横断面分析中，有BV病史的妇女每月至少洗一次液与BV有关，而没有BV病史的妇女则与BV无关。在前瞻性分析中，灌洗只会增加基线时具有中等菌群的女性获得BV的风险（调整HR 1.5，95％CI 1.1-2.4），表明灌洗可能会导致菌群异常的女性发生BV。在病例交叉分析中，一致使用安全套（10次性交中有10次发生）与BV频率降低相关（校正OR = 0.68，95％CI = 0.49-0.94，趋势p = 0.047）。携带人型支原体（调整后的OR = 0.61，95％CI：0.41-0.93）和厌氧革兰氏阴性色素棒（OR = 0.65，95％CI：0.47-0.91）的运输结果相似。这些结果表明，妇女有持续感染的高风险，在有BV病史的妇女中应避免。该研究还提供了避孕套对BV有保护作用的证据。鉴于BV妇女的比例很高，保护因素的识别对于降低BV的流行具有重要的公共卫生意义。

著录项

  • 作者

    Berger, Katherine Helen.;

  • 作者单位

    University of Pittsburgh.;

  • 授予单位 University of Pittsburgh.;
  • 学科 Biology Microbiology.; Health Sciences Public Health.; Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 136 p.
  • 总页数 136
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;预防医学、卫生学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号