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首页> 外文学位 >Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis.
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Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis.

机译：通过组织学和磁共振成像分析可以确定成年大鼠中风后残余皮质组织的变薄，运动和体积损失。

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摘要

Plasticity of residual cortical tissue has been identified as an important mediator of functional post-stroke recovery. After neonatal stroke the thickness of residual tissue can change, the tissue can move, and tissue can fill in the stroke core. Nevertheless, the majority of preclinical stroke research utilizes adult rats. Thus, the purpose of the present thesis was to systematically document such gross morphological changes in peri-infarct tissue after stroke in the adult rat. Morphological changes were assessed in pial strip devascularization, photothrombotic occlusion, and middle cerebral artery occlusion models of stroke using histological and magnetic resonance imaging. Decreases in cortical thickness, volume, and neural density were found to extend far beyond the stroke infarct and included the sensorimotor regions of the intact hemisphere. Movement of residual tissue towards the infarct was observed and confirmed using anatomical markers placed in intact cortical tissue at the time of stroke induction. I conclude that the extensive time-dependent morphological changes that occur in residual cortical tissue must be considered when evaluating plasticity-related cortical changes associated with post-stroke recovery of function.
机译：残余皮质组织的可塑性已经被确定为功能性中风后恢复的重要介质。新生儿中风后，残余组织的厚度可能会改变，组织会移动，组织会填充中风核心。尽管如此，大多数临床前中风研究还是使用成年大鼠。因此，本发明的目的是系统地记录成年大鼠中风后梗塞周围组织的总体形态变化。使用组织学和磁共振成像技术评估了脑卒中的部分皮带血运重建，光血栓栓塞和脑中动脉闭塞模型的形态学变化。发现皮层厚度，体积和神经密度的降低远远超出了中风梗塞范围，并且包括完整半球的感觉运动区域。观察到残余组织向梗塞的运动，并在诱发中风时使用放置在完整皮层组织中的解剖标志物进行了确认。我的结论是，在评估与卒中后功能恢复相关的可塑性相关皮质变化时，必须考虑残留皮质组织中广泛的随时间变化的形态变化。

著录项

  • 作者

    Karl, Jenni M.;

  • 作者单位

    University of Lethbridge (Canada).;

  • 授予单位 University of Lethbridge (Canada).;
  • 学科 Neurosciences.
  • 学位 M.Sc.
  • 年度 2010
  • 页码 162 p.
  • 总页数 162
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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