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首页> 外文学位 >The effects of sucrose or fat ingestion and cocaine administration on locomotor activity and tyrosine hydroxylase in the rat.
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The effects of sucrose or fat ingestion and cocaine administration on locomotor activity and tyrosine hydroxylase in the rat.

机译：蔗糖或脂肪摄入和可卡因给药对大鼠运动能力和酪氨酸羟化酶的影响。

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摘要

Palatable foods such as sucrose may enhance the behavioral effects of cocaine or amphetamine. Manifestation of this enhancement may indicate a cross-sensitization phenomenon parallel to the mechanism of actions of psychostimulants, such cocaine, and palatable foods, such as sucrose. Since dopamine is the major substrate linked to drug addiction, a better understanding of tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis, may suggest novel mechanisms involved in the drug addiction process.; Does sucrose or a fat diet alter locomotion and tyrosine hydroxylase in the mesolimbic pathway? We demonstrated that neither fat nor a sucrose diet altered locomotion. On tyrosine hydroxylase, it was demonstrated that a fat diet significantly increased tyrosine hydroxylase in the ventral tegmental area but not in other brain regions.; Does sucrose or a fat diet influence the locomotor-activating effects of cocaine to enhance cocaine-induced locomotion and sensitization? Cocaine significantly increased locomotor activity on the 1st injection, and sensitization occurred on the 8th injection. However, neither sucrose nor a fat diet enhanced acute cocaine effects (1st injection). Although not significant, sucrose, not fat, tended to enhance cocaine-induced sensitization (8th injection).; Does the combination of a sucrose diet and cocaine, or a fat diet and cocaine affect levels of tyrosine hydroxylase? With a sucrose diet and cocaine, tyrosine hydroxylase in the medial prefrontal cortex and striatum was significantly decreased. Rats fed only chow and administered cocaine had significant decreases of tyrosine hydroxylase in the cortex. Finally, there was a significant decrease of tyrosine hydroxylase in the striatum of sucrose fed rats injected with saline; thus, supporting the theory that palatable foods can alter dopaminergic function. A fat-diet had no significant effects on tyrosine hydroxylase.; From these studies, it was demonstrated that both palatable foods and cocaine can significantly influence tyrosine hydroxylase. Although the effects of palatable food on locomotor activity are less clear, more studies merit further investigations.
机译：蔗糖等可口的食物可能会增强可卡因或苯丙胺的行为效果。表现出这种增强作用可能表明存在与精神兴奋剂（如可卡因）和可口食品（如蔗糖）的作用机理平行的交叉致敏现象。由于多巴胺是与药物成瘾有关的主要底物，因此对酪氨酸羟化酶（多巴胺合成的限速酶）的更好理解可能表明了与药物成瘾有关的新机制。蔗糖或高脂饮食会改变中脑边缘途径中的运动和酪氨酸羟化酶吗？我们证明脂肪和蔗糖饮食都不能改变运动。在酪氨酸羟化酶方面，已证明脂肪饮食显着增加了腹侧被盖区的酪氨酸羟化酶，但在其他脑区域则没有。蔗糖或高脂饮食会影响可卡因的运动激活作用，从而增强可卡因诱导的运动和致敏作用吗？可卡因在第一次注射时显着提高了运动活性，在第八次注射时出现了致敏作用。但是，蔗糖和脂肪饮食都不能增强急性可卡因的作用（第一次注射）。尽管不显着，但蔗糖而非脂肪倾向于增强可卡因诱导的致敏作用（第8次注射）。蔗糖饮食和可卡因的组合，或者脂肪饮食和可卡因的组合是否会影响酪氨酸羟化酶的水平？使用蔗糖饮食和可卡因，内侧前额叶皮层和纹状体中的酪氨酸羟化酶显着降低。只喂食物和服用可卡因的大鼠皮层酪氨酸羟化酶明显减少。最后，注射盐水的蔗糖喂养大鼠的纹状体中酪氨酸羟化酶显着降低。因此，支持可口食品可以改变多巴胺能功能的理论。脂肪饮食对酪氨酸羟化酶无明显影响。这些研究表明，可口的食物和可卡因都可以显着影响酪氨酸羟化酶。尽管可口食品对运动能力的影响尚不清楚，但更多的研究值得进一步研究。

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  • 作者

    Albano, Christian B.;

  • 作者单位

    North Dakota State University.;

  • 授予单位 North Dakota State University.;
  • 学科 Biology Neuroscience.; Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 153 p.
  • 总页数 153
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;预防医学、卫生学;
  • 关键词

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