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首页> 外文学位 >The effects of dietary and fecal phytate associated with fecal minerals: Calcium, copper, iron, and zinc, relative to colonic polyp recurrence.
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The effects of dietary and fecal phytate associated with fecal minerals: Calcium, copper, iron, and zinc, relative to colonic polyp recurrence.

机译：相对于结肠息肉复发，饮食和粪植酸盐与粪便矿物质（钙，铜，铁和锌）相关。

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摘要

Colorectal adenomatous polyps are recognized as precursor lesions in most cases of colorectal cancer. Phytate, found in most plants, is considered by many to be an antinutrient, because it binds divalent cations thus impairing absorption into the body. This study analyzed the levels of phytate and minerals in stored fecal samples to discover whether dietary and fecal phytate in the presence of fecal minerals (Ca, Cu, Fe, and Zn) were related to polyp recurrence in humans. The objectives of the study were to compare and explore the relationships of dietary phytate, and fecal phytate, the fecal phytate:mineral molar ratios (calcium, copper, iron and zinc), to the recurrence of adenomatous polyps. Procedures consisted of retrieval of frozen fecal samples from 50 of the volunteers recruited in the Polyp Prevention Trial (PPT). The fecal samples, the Food Frequency Questionnaire (FFQ), Four-Day Food Records (4DFR), and adenoma recurrence data were provided by the National Cancer Institute. High Performance Liquid Chromatography (HPLC) and Induction Coupled Plasma Emission Spectroscopy (ICP-ES) were used for measuring the levels of dietary and fecal phytate, and minerals (calcium, copper, iron and zinc) in stool samples, respectively. The fecal phytate and mineral data were compiled using descriptive statistics: means, standard deviations, and frequency distributions. The Wilcoxon Rank-Sum test for continuous variables and the chi-square test for categorical variables were used to analyze the results. No significant differences in dietary and fecal phytate relative to the recurrence of colonic polyps and/or higher concentrations of fecal calcium, fecal copper, fecal iron, and fecal zinc relative to fecal phytate concentration were found. In addition, significant relationships between the recurrence of colonic polyps and higher phytate:mineral(s) molar ratios was not observed. All statistical differences were determined at the p ≤ 0.05.
机译：在大多数结直肠癌病例中，结直肠腺瘤性息肉被认为是前体病变。在大多数植物中发现的植酸盐被许多人视为抗营养物质，因为它结合了二价阳离子，从而损害了人体的吸收。这项研究分析了粪便样本中肌醇六磷酸和矿物质的含量，以发现存在粪便矿物质（钙，铜，铁和锌）的饮食和粪便肌醇六磷酸是否与人类息肉复发相关。该研究的目的是比较和探讨饮食中的肌醇六磷酸和粪便肌醇六磷酸，粪便肌醇六磷酸与矿物质的摩尔比（钙，铜，铁和锌）与腺瘤性息肉复发的关系。程序包括从息肉预防试验（PPT）中招募的50名志愿者中收集冰冻的粪便样本。粪便样本，食物频率调查表（FFQ），四天食物记录（4DFR）和腺瘤复发数据由美国国家癌症研究所提供。高效液相色谱（HPLC）和感应耦合等离子体发射光谱（ICP-ES）用于分别测量粪便中的膳食和粪便肌醇六磷酸和矿物质（钙，铜，铁和锌）的水平。粪便的肌醇六磷酸和矿物质数据使用描述性统计数据进行汇编：平均值，标准差和频率分布。使用连续变量的Wilcoxon秩和检验和分类变量的卡方检验来分析结果。相对于结肠息肉的复发和/或相对于粪植酸盐浓度而言，较高的粪钙，粪铜，粪铁和粪锌浓度没有发现饮食和粪植酸盐的显着差异。另外，未观察到结肠息肉的复发与植酸：矿物质的摩尔比较高之间的显着关系。所有统计差异均在p≤0.05时确定。

著录项

  • 作者

    Dixon, Michael O.;

  • 作者单位

    Howard University.;

  • 授予单位 Howard University.;
  • 学科 Agriculture Food Science and Technology.; Chemistry General.; Health Sciences Medicine and Surgery.; Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 199 p.
  • 总页数 199
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 农产品收获、加工及贮藏;化学;预防医学、卫生学;
  • 关键词

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