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Effects of Amygdala Inactivation on Affective Processing by the Nucleus Accumbens.

机译：杏仁核失活对伏隔核情感加工的影响。

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摘要

Inappropriate affect is a major feature of many psychological disorders. Recent progress in the field of affective neuroscience has led to a basic understanding of the brain regions involved in emotional processing. However, this information remains incomplete as we have yet to directly link affective states to specific patterns of brain activity. One area implicated in affective processing is the nucleus accumbens (NAc). Recent studies have shown that the NAc encodes both rewarding and aversive stimuli, and does so by decreasing or increasing its overall activity, respectively. Furthermore, recent studies in our lab have shown that NAc signaling is modified to reflect changes in the affective value of stimuli due to learned associations or changes in motivational state. The NAc serves an important role in translating affective signals into appropriate behavioral action. Thus, signals from other regions could provide essential affective information which influence how NAc neurons respond to stimuli. One candidate source of these signals is the basolateral amygdala (BLA), which sends a glutamatergic projection to the NAc and is thought to link sensory properties of stimuli with affective significance. By inactivating the BLA while monitoring activity in the NAc we can determine the contribution of the BLA to affective processing in the NAc.;In order to accomplish this neural activity was recorded in the NAc of rats exposed to taste stimuli under BLA inactivation. This procedure was used to examine the role of the BLA in NAc encoding of innately rewarding (sucrose) and aversive (quinine) taste stimuli. The role of the central nucleus of the amygdala (CeA) in NAc encoding of taste stimuli was also investigated. This structure receives taste information directly from brainstem regions involved in taste processing and borders the BLA. Thirdly, to test effects of general inactivation of NAc efferents, the ventral subiculum of the hippocampus (Vsub), which also projects directly to the NAc, was inactivated while rats were exposed to rewarding and aversive taste stimuli.
机译：不适当的影响是许多心理障碍的主要特征。情感神经科学领域的最新进展已导致人们对涉及情绪处理的大脑区域有了基本的了解。但是，由于我们尚未将情感状态与大脑活动的特定模式直接关联，因此该信息仍然不完整。与情感加工有关的一个领域是伏伏核（NAc）。最近的研究表明，NAc编码奖励性和厌恶性刺激，并分别通过降低或增加其总体活性来编码。此外，我们实验室中的最新研究表明，NAc信号被修饰以反映由于学习到的联想或动机状态的改变而引起的情感情感价值的变化。 NAc在将情感信号转化为适当的行为行为中起着重要作用。因此，来自其他区域的信号可能会提供基本的情感信息，从而影响NAc神经元对刺激的反应。这些信号的一个候选来源是基底外侧杏仁核（BLA），它向NAc发送了谷氨酸能投射，并被认为将刺激的感觉特性与情感意义联系在一起。通过在监测NAc的活性的同时使BLA失活，我们可以确定BLA对NAc的情感加工的贡献。为了实现这种神经活性，在BLA失活下暴露于味觉刺激的大鼠的NAc中记录了这种神经活性。此程序用于检查BLA在先天奖励（蔗糖）和厌恶（奎宁）味刺激的NAc编码中的作用。还研究了杏仁核（CeA）中央核在NAc编码味觉刺激中的作用。这种结构直接从参与味觉处理的脑干区域接收味觉信息，并且毗邻BLA。第三，为了测试NAc传出的总体失活的效果，当大鼠暴露于奖励性和厌恶性味觉刺激时，也直接投射到NAc的海马腹侧支叶（Vsub）被灭活。

著录项

  • 作者

    Loriaux, Amy Laura.;

  • 作者单位

    University of Illinois at Chicago.;

  • 授予单位 University of Illinois at Chicago.;
  • 学科 Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 200 p.
  • 总页数 200
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遥感技术;
  • 关键词

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